Use of leuprolide to treat endometriosis in a rhesus macaque

Moody KD, K D Moody, Percy DH, D H Percy, M A Papero, Papero Ma, S E Morgenstern, Morgenstern Se
Laboratory animal science · 1991 · vol. 41(5) , pp. 427–31 · PMID:1666142 · W2408719093
Case report OA: closed CC0 ⤵ 5 in-corpus citations
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Leuprolide treatment of endometriosis in a rhesus macaque led to cessation of menses and clinical improvement, but the animal later deteriorated and required euthanasia.

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Abstract

Endometriosis was diagnosed in an aged dysmenorrheic rhesus monkey (Macaca mulatta) after biopsy of a 7 cm abdominal mass which could not be completely resected due to extensive adhesions. A 6-month course of treatment with leuprolide, a gonadotropin-releasing hormone agonist, resulted in cessation of menstrual cycles and marked clinical improvement. Dysmenorrhea and hypovolemic shock occurred 2 months after therapy was completed. Despite supportive treatment and resumption of leuprolide, the primate's clinical deterioration and abdominal mass enlargement necessitated euthanasia. To our knowledge, this is the first report of a case of endometriosis in a rhesus macaque treated with a gonadotropin-releasing hormone agonist. Although prolonged leuprolide therapy was clinically effective, its cost and the difficulty in early diagnosis of endometriosis may limit its use in nonhuman primate medicine.

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Condition tags

endometriosisdysmenorrhea

MeSH descriptors

Endometriosis Leuprolide Macaca mulatta Macaca mulatta Monkey Diseases Animals Animals Endometriosis Endometriosis Endometriosis Endometriosis Female Female Leuprolide Leuprolide Monkey Diseases Monkey Diseases Monkey Diseases

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (5)

SciLite annotations

chemicals 3
leuprolide leuprolide leuprolide
organisms 6
rhesus monkeys rhesus monkeys rhesus monkeys primates rhesus monkeys primate papillomaviruses

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