Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation

Sadia Afrin, Malak El Sabeh, Md Soriful Islam, Mariko Miyashita‐Ishiwata, Minnie Malik, William H. Catherino, Askar M. Akimzhanov, Darren Boehning, Qiwei Yang, Ayman Al‐Hendy, James H. Segars, Mostafa A. Borahay
In: Pharmacological Research · 2021 · vol. 172 , pp. 105856 · doi:10.1016/j.phrs.2021.105856 · PMID:34461224 · W3197124121
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This paper investigated how simvastatin affects estrogen signaling in uterine leiomyoma by altering the palmitoylation, trafficking, and degradation of estrogen receptors.

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last seen: 2026-06-10T17:14:06.276822+00:00
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