Darren Boehning

ORCID: 0000-0001-7920-6922 · 2 papers in corpus

article 2021

Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation

·doi:10.1016/j.phrs.2021.105856

Uterine leiomyomas or fibroids are the most common tumors of the female reproductive tract. Estrogen (E2), a steroid-derived hormone, and its receptors (ERs), particularly ER-α, are important drivers for the development and growth of leiomy…

2015

Novel effects of simvastatin on uterine fibroid tumors: in vitro and patient-derived xenograft mouse model study.

American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2015.03.055

ObjectiveUterine leiomyomas represent a common gynecologic problem with no satisfactory long-term medical treatment. The purpose of this study is to examine the effects of simvastatin on uterine leiomyoma, both in vitro and in vivo.Study de…