Stimuler la femme ovulatoire

In: Pratique de la stimulation ovulatoire par les gonadotrophines · 2013 · pp. 109–122 · doi:10.1007/978-2-8178-0398-2_10 · W4210425244
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AI-generated summary by claude@2026-06+body, 2026-06-13

Monofollicular stimulation is the first-line treatment for young women, while bifollicular stimulation carries multiple pregnancy risks and paucifollicular stimulation should be avoided.

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The paper describes goals and decision points for ovarian stimulation in spontaneously ovulating women, focusing on monofollicular, bifollicular, and paucifollicular strategies used to induce ovulation for fertility treatment. It reports that monofollicular stimulation is positioned as first-line for younger women (e.g., <35), especially with lower BMI, shorter infertility duration, and in the context of IUI for cervical-factor infertility, while bifollicular stimulation increases the risk of multiple pregnancy and should only be considered when the potential benefit outweighs factors such as altered ovarian reserve, age, pelvic anomalies (including endometriosis), or suboptimal semen. A limitation emphasized is the inherent risk trade-off, particularly that higher-order follicle development (3–5 mature follicles) is generally discouraged except possibly in carefully informed, selected patients after prior cycle failures. Relevance to endometriosis: the paper explicitly lists endometriosis as a pelvic factor that can tilt the balance against bifollicular stimulation risk, though the paper’s main focus is ovarian stimulation strategy in spontaneously ovulatory women.

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Résumé Chez la femme qui ovule spontanément, la stimulation classique peut connaître plusieurs objectifs: - la stimulation monofolliculaire, qui a pour ambition de mimer au plus près le cycle physiologique: elle reste impérative en première intention chez la femme jeune (< 35 ans), surtout à faible BMI, infertile depuis moins de trois ans, et en cas d’IUI pour infertilité d’origine cervicale; - la stimulation bifolliculaire fait encourir le risque d’une grossesse multiple, essentiellement gémellaire; si cette éventualité est assez généralement bien admise par le couple infertile qui peine déjà depuis plusieurs années, il n’en est pas moins vrai que la grossesse gémellaire reste une grossesse à risque, et à pronostic parfois aléatoire. C’est pourquoi ce risque ne peut médicalement être pris que si l’espoir d’un taux de grossesse supérieur, en disposant d’un ovocyte supplémentaire pour un rapport ou une insémination, ne fait que contrebalancer un handicap comme une réserve ovarienne altérée, le facteur âge, une anomalie pelvienne (trompe unique, endométriose…), un sperme suboptimal…ou une infertilité inexpliquée; - la stimulation paucifolliculaire: déclencher l’ovulation en présence de 3 à 5 follicules matures est un risque à ne pas prendre, sauf peut-être chez une patiente de plus de 40 ans, volontaire et dûment informée, et seulement après un ou plusieurs échecs de cycles mono-ou bifolliculaires. Preview Unable to display preview. Download preview PDF. Références Loumaye E (1995) A phase III, open, randomized, multicentre study to compare the safety and efficacity of recombinant human follicle stimulating hormone (Gonal F) administered subcutaneously with that of urinary human follicle stimulating hormone (Metrodin) given intramuscularly, to induce ovulation in WHO group II anovulatory infertile women. ARES SERONO, Internal Report. Dickey RP, Taylor SN, Lu PY, et al. (2001) Relationship of follicle numbers and œstradiol levels to multiple implantation in 3.608 intrauterine insemination cycles. Fertil Steril 75: 69–78 Vers la grossesse monofoetale en AMP (2009) Gyn Obst Fertil 37, Hors-serie nº 1,1–26 Antoine JM, Audebert A, Avril C, et al. (2004) Traitement de la stérilité et grossesses multiples en France: analyse et recommandations. Gyn Obstet Fertil 32: 670–83 Cedrin Durnerin I, Massin N, Galey-Fontaine J, et al. (2006) Timing of FSH administration for ovarian stimulation in normo-ovulatory women: comparison of an early or a mid follicular phase initiation of a short-term treatment. Hum Reprod 21: 2941–7 Belaisch Allart J (2009) Peut-on prévenir les grossesses multiples hors FIV ? Gynecol Obstet Fertil 37: 6–8 Tur R, Barri PN, Coroleu B, et al. (2005) Use of a prediction model for high-order multiple implantation after ovarian stimulation with gonadotrophins. Fertil Steril 83: 116–21 Belaisch Allart J, Mayenga JM, Grefenstette I, et al. (2007) Insémination intrautérine: pourquoi continuer à stimuler l’ovulation ? Gynecol Obstet Fertil 35: 871–6 Author information Authors and Affiliations Rights and permissions Copyright information © 2013 Springer-Verlag France About this chapter Cite this chapter Emperaire, JC. (2013). Stimuler la femme ovulatoire. In: Pratique de la stimulation ovulatoire par les gonadotrophines. Springer, Paris. https://doi.org/10.1007/978-2-8178-0398-2_10 Download citation DOI: https://doi.org/10.1007/978-2-8178-0398-2_10 Publisher Name: Springer, Paris Print ISBN: 978-2-8178-0397-5 Online ISBN: 978-2-8178-0398-2 eBook Packages: MedicineMedicine (R0)

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