Early ovarian ageing: a hypothesis. Detection and clinical relevance

Dimitrios Nikolaou, D Nikolaou, A Templeton
Human Reproduction · 2003 · vol. 18(6) , pp. 1137–1139 · doi:10.1093/humrep/deg245 · PMID:12773436 · W2053962663
Review OA: bronze CC0 ⤵ 6 in-corpus citations
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IVF data suggest a fixed interval between fertility decline and menopause, leading to a hypothesis that younger women may risk early subfertility, with IVF models aiding ovarian reserve test development.

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Abstract

An important scientific breakthrough of the 20th century, IVF helped open new horizons in medicine, such as pre-implantation genetic diagnosis and embryonic stem-cell therapy. A further contribution of assisted reproduction technology has been the better understanding of reproductive ageing. Data from IVF cycles suggest that there is a fixed time-interval between accelerated decline of fertility and the menopause. This leads to the hypothesis that a significant proportion of asymptomatic women in the early thirties may be at risk of early onset of subfertility. IVF provides a model for the development of ovarian reserve tests, some of which appear promising as potential screening tools for early ovarian ageing in the general population.

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MeSH descriptors

Aging Ovary Primary Ovarian Insufficiency Adult Female Fertilization in Vitro Humans Infertility, Female Menopause Middle Aged Ovarian Follicle Ovary Primary Ovarian Insufficiency Time Factors

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