Epithelial-mesenchymal transition as an important stage in the formation of pathological proliferative diseases of the uterus

E.G. Shvarev, A.R. Zoeva, И. В. Зайцев
In: Russian Bulletin of Obstetrician-Gynecologist · 2025 · vol. 25(4) , pp. 37 · doi:10.17116/rosakush20252504137 · W4413223300
article OA: closed CC0
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses epithelial-mesenchymal transition's role in uterine hyperplastic diseases and cancer, proposing menstrual secretions as an alternative diagnostic tool.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper reviews epithelial–mesenchymal transition (EMT) as a key biological stage in the development of pathological proliferative uterine diseases, drawing on evidence from studies of uterine epithelium biology, EMT regulation, and tumor progression mechanisms. It synthesizes findings across topics such as endometrial function and repair, mesenchymal–epithelial plasticity, and EMT involvement in uterine and endometrioid cancer contexts, while discussing molecular pathways and major mechanistic themes. A major limitation is that, as a narrative overview, it does not present new original experiments or a standardized, systematic method to quantify the strength of evidence across included studies. Relevance to endometriosis: the paper cites work connecting EMT/microenvironmental mechanisms to endometriosis, including a question of when EMT occurs in endometriosis, though its main focus is EMT in the formation of pathological proliferative uterine diseases.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

The review is devoted to the presentation of modern knowledge about the mechanisms of reversible transformation of epithelial and mesenchymal cells of the endometrium, about the impact of this process on changes in a woman’s reproductive health, including the formation of hyperplastic processes and endometrial cancer. It is known that to study the structural and functional state of the endometrium, a biopsy is usually required, which is currently most often performed by an invasive transcervical method. The presented material suggests consideration of an alternative approach to the diagnosis of these diseases, based on the identification of markers of the epithelial-mesenchymal and mesenchymal-epithelial transition in the menstrual secretions of the examined patients and thereby determining indications for treatment by various methods. The purpose of the review is to provide up—to-date information on the processes of epithelial-mesenchymal and mesenchymal-epithelial transitions, their involvement in the regulation of physiological functions of the uterus, as well as in the pathogenesis of hyperplastic processes in the endometrium and endometrial cancer, and to consider the possibility of forming a new approach to the detection of these diseases. To achieve this goal, a search was conducted for domestic and foreign studies in the Pubmed international citation system published over the past 15 years. Modern data on the main mechanisms of epithelial-mesenchymal and mesenchymal-epithelial transition at the stages of the menstrual cycle in healthy women, as well as during the formation of hyperproliferative endometrial diseases, including the risk of their malignancy, are presented.
Full text 12,791 characters · extracted from oa-doi-fallback · click to expand
Сайт издательства «Медиа Сфера» содержит материалы, предназначенные исключительно для работников здравоохранения. Закрывая это сообщение, Вы подтверждаете, что являетесь дипломированным медицинским работником или студентом медицинского образовательного учреждения. Результаты поиска: 0 Эпителиально-мезенхимальный переход как важный этап формирования патологических пролиферативных заболеваний матки Журнал: Российский вестник акушера-гинеколога. 2025;25(4): 37‑43 Прочитано: 856 раз Как цитировать: Литература / References: - Endometrial Cancer Statistics World Cancer Research Fund International. [(accessed on 5 August 2022)]. https://www.wcrf.org/cancer-trends/endometrial-cancer-statistics/ - Global Cancer Observatory. WHO Cancer Today. [(accessed on 11 November 2022)]. https://gco.iarc.fr/today/home. - Ghoubara A, Sundar S, Ewies AAA. Endometrial pathology in recurrent postmenopausal bleeding: observational study of 385 women. Climacteric. 2018:391-396. https://doi.org/10.1080/13697137.2018.1461825 - Кузнецова И.В. Российские и международные подходы к ведению пациентов с гиперплазией эндометрия. Акушерство и гинекология. Портал CON-MED.RU. 2020. - Клинические рекомендации. Гиперплазия эндометрия. Кодирование по Международной статистической классификации болезней и проблем, связанных со здоровьем: N85.0, N85.1. Разработчик клинических рекомендаций — Российское общество акушеров-гинекологов. 2021. - Boeckstaens S, Dewalheyns S, Heremans R, Vikram R, Timmerman D, Van den Bosch T, Verbakel JY. Signs and symptoms associated with uterine cancer in pre- and postmenopausal women. Heliyon. 2020;6:11:e05372. https://doi.org/10.1016/j.heliyon.2020.e05372 - Шамилова А.М., Ильина И.Ю., Боровкова Е.И., Доброхотова Ю.Э. Хронический эндометрит. Пути улучшения методов диагностики. РМЖ. Мать и дитя. 2021;3:243-249. https://doi.org/10.32364/2618-8430-2021-4-3-243-249 - Guo J, Zhou W, Sacco M., Downing P., Dimitriadis E., Zhao F. Using organoids to investigate human endometrial receptivity Review. Front Endocrinol (Lausanne). 2023;24:14:1158515. https://doi.org/10.3389/fendo.2023.1158515 - Maybin JA, Critchley HOD. Menstrual physiology: implications for endometrial pathology and beyond. Hum Reprod Update. 2015; 21:6:748-761. https://doi.org/10.1093/humupd/dmv038 - Eremichev R, Kulebyakina M, Alexandrushkina N, Nimiritsky P, Basalova N, Grigorieva O, Egiazaryan M, Dyikanov D, Tkachuk V. Scar-free healing of endometrium: tissue-specific program of stromal cells and its induction by soluble factors produced after damage front. Cell Dev. Biol. 2021;25:9:616893. https://doi.org/10.3389/fcell.2021.616893 - Critchley HOD, Babayev E, Bulun SE, Clark S, Garcia-Grau I, Gregersen PK, Kilcoyne A, Kim JJ, Lavender M, Marsh EE, Matteson KA, Maybin JA, Metz CN, Moreno I, Silk K, Sommer M, Simon C, Tariyal R., Taylor HS, Wagner GP, Griffith LG. Menstruation: science and society. Review. Am J Obstet Gynecol. 2020;223:5:624-664. https://doi.org/10.1016/j.ajog.2020.06.004 - Reavey JJ, Walker C, Nicol M, Murray AA, Critchley HOD, Kershaw LE, Maybin JA. Markers of human endometrial hypoxia can be detected in vivo and ex vivo during physiological menstruation. Hum Reprod. 2021;36:4: 941-950. https://doi.org/10.1093/humrep/deaa379 - Hu X, Wu H, Yong X, Wang Y, Yang S, Fan D, Xiao Y, Che L, Shi K, Li K, Xiong C, Zhu H, Qian Z. Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions. MedComm. 2023;4:6:e425. https://doi.org/10.1002/mco2.425 - Оразов М.Р., Михалева Л.М., Муллина И.А. Прогнозирование рецидивирующей гиперплазии эндометрия. (Обзор). Трудный пациент. 2021;19:7:6-8. - Walther-António MRS, Chen J, Multinu F, Hokenstad A, Distad TJ, Cheek EH, Keeney GL, Creedon DJ, Nelson H, Mariani A, Chia N. Potential contribution of the uterine microbiome in the development of endometrial cancer. Genome Med. 2016;25:8:1:122. https://doi.org/10.1186/s13073-016-0368-y - Morańska K, Englert-Golon M, Durda-Masny M, Sajdak S, Grabowska M, Szwed A. Why does your uterus become malignant? The Impact of the microbiome on endometrial carcinogenesis. Life (Basel). 2023;13:12:2269. https://doi.org/10.3390/life13122269 - Maruyama T, Miyazaki K, Masuda H, Ono M, Uchida H, Yoshimura Y. Review: Human uterine stem/progenitor cells: implications for uterine physiology and pathology. Placenta. 2013; 34:68-72. https://doi.org/10.1016/j.placenta.2012.12.010 - Evans J, Infusini G, McGovern J, Cuttle L, Webb A, Nebl T, Milla L, Kimble R, Kempf M, Andrews CJ, Leavesley D, Salamonsen LA. Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair. Faseb J. 2019;33:584-605. https://doi.org/10.1096/fj.201800086R - Owusu-Akyaw A, Krishnamoorthy K, Goldsmith LT, Morelli SS. The role of mesenchymal-epithelial transition in endometrial function. Hum Reprod Update. 2019;25:1:114-133. https://doi.org/10.1093/humupd/dmy035 - Украинец Р.В., Корнева Ю.С. Эпителиально-мезенхимальный переход и его связь с синдромом повышенной кишечной проницаемости как возможное звено в патогенезе эндометриоза. Проблемы репродукции. 2020;26:5:133-140. https://doi.org/10.17116/repro202026051133 - Crha K, Ventruba P, Žáková J, Ješeta M, Pilka R, Vodička J, Serpa P. The role of mesenchymal-epithelial transition in endometrial function and receptivity. Ceska Gynekol. 2019;84:5:371-375. - Gargett CE, Schwab KE, Zillwood RM, Nguyen H, Di Wu. Isolation and culture of epitelial progenitors and mesenchymal stem cells from the human endometrium. Reprod Sci. 2009;80:6:1136-1145. - Mutlu L, Hufnagel D, Taylor HS. The endometrium as a source of mesenchymal stem cells for regenerative medicine. Biol Reprod. 2015;92:6:138. https://doi.org/10.1095/biolreprod.114.126771 - Nimiritsky PP, Eremichev RY, Alexandrushkina NA, Efimenko AY, Tkachuk VA, Makarevich PI. Unveiling mesenchymal stromal cells’ organizing function in regeneration. Int J Mol Sci. 2019; 20:20040823. https://doi.org/10.3390/ijms20040823 - Аникина Т.А., Сысоева В.Ю., Рубина К.А., Радзинский В.Е. Экспрессия маркеров клеточного цикла мезенхимными клетками нормального эндометрия и эндометрия при пролиферативных заболеваниях матки. Акушерство и гинекология. 2016;9:79-86. https://doi.org/10.18565/aig.2016.9.79-86 - Казачкова Э.А., Затворницкая А.В., Воропаева Е. Е., Казачков Е.Л. Гиперплазия эндометрия, сочетающаяся с хроническим эндометритом: клинико-морфологические особенности. Уральский медицинский журнал. 2020;3:186:36-41. - Vereshchahina TV, Boychuk AV, Yakymchuk YB, Nikitina IM, Datsko TV. Morphological changes of the endometrium in hyperplastic process in women of reproductive age. Wiad Lek. 2021; 74:388-394. - Owusu-Akyaw A, Krishnamoorthy K, Goldsmith LT, Morelli SS. The role of mesenchymal-epithelial transition in endometrial function. Hum Reprod Update. 2019;25:114-133. https://doi.org/10.1093/humupd/dmy035 - Critchley HOD, Maybin JA, Armstrong GM, Williams ARW. Physiology of the endometrium and regulation of menstruation. Physiol Rev. 2020;100:3:1149-1179. https://doi.org/10.1152/physrev.00031.2019 - Montserrat N, Mozos A, Llobet D, Dolcet X, Pons C, García de Herreros A, Matias-Guiu X, Jaime Prat. Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma. Hum Pathol. 2012;43:5:632-643. https://doi.org/10.1016/j.humpath.2011.06.021 - Haerinck J, Goossens S, Berx G. The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation. Nat Rev Genet. 2023;24:9:590-609. https://doi.org/10.1038/s41576-023-00601-0 - Konrad L, Dietze R, Riaz MA, Scheiner-Bobis G, Behnke J, Horné F, Hoerscher A, Reising C, Meinhold-Heerlein I. Epithelial-mesenchymal transition in endometriosis-When does it happen? J Clin Med. 2020;9:6:1915. https://doi.org/10.3390/jcm9061915 - Bieging KT, Mello SS, Attardi LD. Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer. 2014;14:5:359-370. - Nakanishi A, Kitagishi Y, Ogura Y, Matsuda S. The tumor suppressor PTEN interacts with p53 in hereditary cancer (Review). Int J Oncol. 2014;44:6:1813-1819. https://doi.org/10.3892/ijo.2014.2377 - Xing Z, Danhua S, Xiaobo Z. Diagnostic validity of p16, E-cadherin, cyclin D1, p53, and HPV E6/E7 mRNA in CIN 3-like squamous cell carcinoma of the cervix. Front Oncol. 2024;14:1354838. https://doi.org/10.3389/fonc.2024.1354838 - Djokovic D, Calhaz-Jorge C. Somatic stem cells and their dysfunction in endometriosis. Front Surg. 2015;1:51. https://doi.org/10.3389/fsurg.2014.00051 - Глушанкова Н.А., Житняк И.Ю., Рубцова С.Н. Роль эпителиально-мезенхимального перехода в опухолевой прогрессии (обзор). Биохимия. 2018;83:1802-1811. https://doi.org/10.1134/S0320972518120059 - Makker A, Goel MM. Tumor progression, metastasis, and modulators of epithelial-mesenchymal transition endometrioid endometrial carcinoma: an update. Endocr Relat Cancer. 2016;23:2:85-111. https://doi.org/10.1530/ERC-15-0218 - Ang HL, Mohan CD, Shanmugam MK, Leong HC, Makvandi P, Rangappa KS, Bishayee A, Kumar AP, Sethi G. Mechanism of epithelial-mesenchymal transition in cancer and its regulation by natural compounds. Med Res Rev. 2023;43:4:1141-1200. https://doi.org/10.1002/med.21948 - Toropov AL, Deryabin PI, Shatrova AN, Borodkina AV. Oncogene-induced senescence is a crucial antitumor defense mechanism of human endometrial stromal cells. Int J Mol Sci. 2023; 24:18:14089. https://doi.org/10.3390/ijms241814089 - Bilyk O, Coatham M, Jewer M, Postovit LM. Epithelial-to-mesenchymal transition in the female reproductive tract: From Normal functioning to disease pathology. Front Oncol. 2017;7:145. https://doi.org/10.3389/fonc.2017.00145 - Jin Y, Qiu Y, Li Y, Jiang Z, Hu S, Dai H. A novel epithelial-mesenchymal transition-related lncRNA signature predicts prognosis and immune status in endometrioid endometrial cancer. Medicine (Baltimore). 2023;102:26:e34126. https://doi.org/10.1097/MD.0000000000034126 - Liu J, Cui G, Shen S, Gao F, Zhu H, Xu Y. Establishing a prognostic signature based on epithelial-mesenchymal transition-related genes for endometrial cancer patients. Front Immunol. 2022; 12:805883. https://doi.org/10.3389/fimmu.2021.805883 - Shu W, Wang Z, Zhang W, Zhang J, Zhao R, Yu Z, Dong K, Wang H. Identification of EMT-associated LncRNA signature for predicting the prognosis of patients with endometrial cancer. Comb Chem High Throughput Screen. 2023;26:8:1488-1502. https://doi.org/10.2174/1386207325666221005122554 - Wu S, Wu G, Li Y, Wu H. Mechanism of HCG regulating epithelial-mesenchymal transition progression in endometrial cells through the FoxO1/miR223-5p/Wnt5α pathway. Reprod Biomed Online. 2024;48:1:103246. https://doi.org/10.1016/j.rbmo.2023.05.016 - Yu Y, Zhang Y, Li Z, Dong Y, Huang H, Yang B, Zhao E, Chen Y, Yang L, Lu J, Qiu F. An EMT-related genes signature as a prognostic biomarker for patients with endometrial cancer. BMC Cancer. 2023;23:1:879. https://doi.org/10.1186/s12885-023-11358-4 - Donoso MB, Serra R, Rice GE, Gana MT, Rojas C, Khoury M, Arraztoa JA, Monteiro LJ, Acuña S, Illanes SE. Normality ranges of menstrual fluid. Volume during reproductive life using direct quantification of menses with vaginal cups. Gynecol Obstet Invest. 2019;84:4:390-395. https://doi.org/10.1159/000496608 - Hewitt SC, Dickson MJ, Edwards N, Hampton K, Garantziotis S, DeMayo FJ. From cup to dish: how to make and use endometrial organoid and stromal cultures derived from menstrual fluid. Front Endocrinol (Lausanne). 2023;14:1220622. https://doi.org/10.3389/fendo.2023.1220622 - Качалина Т.С., Мотовилова Т.М., Боровкова Л.В., Гречканев Г.О., Пономарева И.В., Пучкова Т.Н., Мартьянцева И.В., Замыслова В.П., Зиновьева О.С., Чикалова К.И., Сиротина Л.З. Интегративная оценка биомаркеров менструальной крови в диагностике неопухолевой патологии эндометрия. Акушерство и гинекология. 2019;3:121-126. https://doi.org/10.18565/aig.2019.3.121-126 - Gupta D, Hull ML, Fraser I, Miller L, Bossuyt PM, Johnson N, Nisenblat V. Endometrial biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst. 2016;20;4:4:CD012165. https://doi.org/10.1002/14651858.CD012165 - Cindrova-Davies T, Zhao X, Elder K, Jones CJP, Moffett A, Burton GJ, Turco MY. Menstrual flow as a non-invasive source of endometrial organoids. Commun Biol. 2021;4:1:651. https://doi.org/10.1038/s42003-021-02194-y Подтверждение e-mail На [email protected] отправлено письмо со ссылкой для подтверждения e-mail. Перейдите по ссылке из письма, чтобы завершить регистрацию на сайте. Подтверждение e-mail Мы используем файлы cооkies для улучшения работы сайта. Оставаясь на нашем сайте, вы соглашаетесь с условиями использования файлов cооkies. Чтобы ознакомиться с нашими Положениями о конфиденциальности и об использовании файлов cookie, нажмите здесь.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-06-04T02:00:05.705006+00:00
License: CC0 · commercial use OK