Measurement of serosal temperatures and depth of thermal injury generated by thermal balloon endometrial ablation in ex vivo and in vivo models

Arjav A Shah, A A Shah, S A Stabinsky, Seth A. Stabinsky, T Klusak, Thomas Klusak, Kent R Bradley, K R Bradley, J F Steege, John F. Steege, David W. Grainger, David A Grainger, D A Grainger
Fertility and sterility · 1998 · vol. 70(4) , pp. 692–697 · doi:10.1016/s0015-0282(98)00245-3 · PMID:9797100 · W2077138232
Other OA: closed CC0 ⤵ 6 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This study measured serosal temperatures and thermal injury depth during thermal balloon endometrial ablation in ex vivo and in vivo models.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To evaluate the safety profile of endometrial ablation performed with a thermal balloon as defined by serosal temperature elevation and depth of injury. DESIGN: Observational study with histopathologic correlation conducted in ex vivo and in vivo phases. SETTING: Academic medical center. PATIENT(S): Twenty patients undergoing total abdominal hysterectomy. INTERVENTION(S): Endometrial ablation with a thermal balloon. MAIN OUTCOME MEASURE(S): Serosal temperature elevation and histologic depth of injury. RESULT(S): Ex vivo phase results revealed serosal temperatures remained within a safe physiologic range (<45 degrees C). Greatest depth of myometrial injury in the premenopausal uteri was 5.8 mm over the anterior lower uterine segment. In postmenopausal uterus. the greatest depth of myometrial injury was 3.8 mm in the anterior midline. In vivo phase results revealed mean (+/- SD) peak serosal temperatures of 36.1 +/- 1.6 degrees C. As with the ex vivo phase. histologic examination revealed deep endometrial and superficial myometrial damage to all areas. The greatest depth of myometrial injury occurred in the midfundus at 3.4 mm. CONCLUSION(S): No patients experienced complications or adverse events secondary to treatment. Results showed that transuterine thermal injury is a highly unlikely scenario. In both phases of this study, histologic examination revealed that temperatures exposed to the endometrial layer were sufficient to cause tissue damage.

My notes (saved in your browser only)

MeSH descriptors

Catheter Ablation Catheterization Hyperthermia, Induced Menorrhagia Adult Body Temperature Regulation Body Temperature Regulation Case-Control Studies Catheter Ablation Catheterization Endometrium Feasibility Studies Female Humans Hysterectomy Menorrhagia Middle Aged Models, Biological

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

Cited by (6)

Source provenance

openalex
last seen: 2026-05-11T06:24:00.257642+00:00
pubmed
last seen: 2026-10-08T22:00:48.437354+00:00
unpaywall
last seen: 2026-08-12T06:43:03.944938+00:00
License: CC0 · commercial use OK