An in vitro uterine perfusion model for investigating endometrial cryoablation

Julia F. Bodle, Sean Duffy, David M. Binney
In: Journal of Minimally Invasive Gynecology · 2007 · vol. 14(3) , pp. 329–333 · doi:10.1016/j.jmig.2006.11.011 · PMID:17478364 · W2123453558
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper describes an in vitro uterine perfusion model developed for studying the effects of endometrial cryoablation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Study objectivesTo build a simple in vitro uterine perfusion model for investigating the clinical effectiveness of endometrial ablation.DesignComparative laboratory and in vivo study (Canadian Task Force classification II-2).SettingUniversity teaching hospital.PatientsWomen undergoing hysterectomy for menorrhagia with uteri of normal shape and size.InterventionsA single 5-minute freeze, followed by an active thaw was applied to the endometrial cavity of uteri in vivo and in the in vitro perfusion model.Measurements and main resultsEndometrial/myometrial temperature change was measured continuously during the cryosurgical procedure. Depth of cell death was measured using nicotinamide adenine dinucleotide diaphorase enzyme assay. There was no significant difference in temperature change and depth of cell death in endometrial/myometrial tissue between in vivo and in vitro perfusion experiments.ConclusionsThe in vitro perfusion model described is a useful tool for investigating endometrial cryoablation and has potential for investigating and developing other intrauterine surgical modalities.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Source provenance

openalex
last seen: 2026-05-14T06:04:04.317202+00:00
License: CC0 · commercial use OK