Measurement of serosal temperatures and depth of thermal injury generated by thermal balloon endometrial ablation in ex vivo and in vivo models

Arjav A Shah, Seth A. Stabinsky, Thomas Klusak, Kent R Bradley, John F. Steege, David W. Grainger, David A Grainger
In: Fertility and Sterility · 1998 · vol. 70(4) , pp. 692–697 · doi:10.1016/s0015-0282(98)00245-3 · PMID:9797100 · W2077138232
article OA: closed CC0 ⤵ 6 in-corpus citations
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This study measured serosal temperatures and thermal injury depth during thermal balloon endometrial ablation in ex vivo and in vivo models.

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Abstract

ObjectiveTo evaluate the safety profile of endometrial ablation performed with a thermal balloon as defined by serosal temperature elevation and depth of injury.DesignObservational study with histopathologic correlation conducted in ex vivo and in vivo phases.SettingAcademic medical center.Patient(s)Twenty patients undergoing total abdominal hysterectomy.Intervention(s)Endometrial ablation with a thermal balloon.Main outcome measure(s)Serosal temperature elevation and histologic depth of injury.Result(s)Ex vivo phase results revealed serosal temperatures remained within a safe physiologic range (<45 degrees C). Greatest depth of myometrial injury in the premenopausal uteri was 5.8 mm over the anterior lower uterine segment. In postmenopausal uterus. the greatest depth of myometrial injury was 3.8 mm in the anterior midline. In vivo phase results revealed mean (+/- SD) peak serosal temperatures of 36.1 +/- 1.6 degrees C. As with the ex vivo phase. histologic examination revealed deep endometrial and superficial myometrial damage to all areas. The greatest depth of myometrial injury occurred in the midfundus at 3.4 mm.Conclusion(s)No patients experienced complications or adverse events secondary to treatment. Results showed that transuterine thermal injury is a highly unlikely scenario. In both phases of this study, histologic examination revealed that temperatures exposed to the endometrial layer were sufficient to cause tissue damage.

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