B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population

Amber M. Klimczak, Klimczak AM, Herlihy NS, Nola S. Herlihy, Cynthia S. Scott, Scott CS, Hanson BM, Brent M. Hanson, Julia G. Kim, Kim JG, Shiny Titus, Titus S, Seli E, Emre Seli, Scott RT Jr, Richard T. Scott, Richard Thomas Scott
Fertility and sterility · 2021 · vol. 117(2) , pp. 351–358 · doi:10.1016/j.fertnstert.2021.09.036 · PMID:34809978 · W3215120206
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This study investigated the association between B-cell lymphoma 6 expression and live birth rates in women undergoing in vitro fertilization who responded normally to ovarian stimulation.

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Abstract

OBJECTIVE: To determine whether increased endometrial B-cell lymphoma 6 (BCL6) expression is associated with live birth in a normal responder in vitro fertilization (IVF) population. DESIGN: Case-control study. SETTING: University-affiliated infertility center. PATIENT(S): Two groups of women undergoing IVF with preimplantation genetic testing for aneuploidy followed by warmed, single, euploid embryo transfer. Group 1 consisted of women who failed to achieve live birth, and group 2 consisted of women who achieved live birth. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Endometrial BCL6 expression measured by immunohistochemistry in endometrial tissue samples. Overexpression was defined by mean HSCORE with a cutoff of positivity of >1.4, as previously described in the literature. RESULT(S): Twenty-seven patients who achieved live birth and 23 patients who failed to achieve live birth were included. B-cell lymphoma 6 expression/HSCORE and live birth rate were not associated (Odds ratio [OR], 0.78 [0.24-2.55]). Using a cutoff of >1.4 for positivity, 8 of 23 samples were positive for BCL6 in the no live birth group, whereas 7 of 27 were positive in the live birth group. There was no significant association between BCL6 positivity and live birth (OR, 0.66 [0.19-2.21]). CONCLUSION(S): The proportion of patients with BCL6 positivity did not significantly differ between those who achieved live birth and those who did not. In the population of patients at our center, who compromise of women who respond normally to IVF stimulation, BCL6 overexpression was not associated with IVF success. Physicians implementing BCL6 testing as a diagnostic tool for clinical decision making should counsel patients that results may have limited utility in predicting IVF outcomes in this population.

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MeSH descriptors

Endometrium Fertilization in Vitro Fertilization in Vitro Fertilization in Vitro Infertility Proto-Oncogene Proteins c-bcl-6 Adolescent Adolescent Adult Adult Case-Control Studies Case-Control Studies Embryo Implantation Embryo Implantation Endometrium Endometrium Endometrium Female Female Fertility

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