The effect of personalized invalidation of symptoms by healthcare providers on patient depression: The mediating role of self-esteem
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This study examined how personalized invalidation of symptoms by healthcare providers impacts patient depression, exploring the mediating influence of self-esteem.
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Abstract
ObjectivesQualitative research has thoroughly investigated the diagnostic journeys of patients, who have often reported difficulty with healthcare providers regarding the acknowledgement of an organic, pathological cause for their symptoms (hereafter referred to as invalidation of symptoms). These encounters also reportedly contributed to reductions in self-esteem and to feelings of depression, particularly prior to diagnosis. The aim of this research was to quantitatively validate these observed relationships and examine the potential compounding effect of personalization of this reported invalidation.MethodsParticipants were 609 patients with self-reported endometriosis from a larger online research study. Invalidation and personalization of invalidation were measured with survey items developed for this research. Self-esteem and depression were assessed with well-known validated and reliable self-report instruments. Hierarchical linear regressions were performed, with path analysis to test for mediation.ResultsInvalidation predicted self-esteem but not depression. However, when personalized, invalidation predicted both self-esteem and depression. Path analysis testing the effect of personalization of invalidation on depression through self-esteem was significant, demonstrating full mediation.ConclusionsResults confirm qualitative research and provide the first known quantitative support that invalidation, particularly when personalized, can be associated with reduced self-esteem and, in turn, greater depression.Practice implicationsThese findings demonstrate an important barrier to patient-centered communication.
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Cited by (5)
- Effect of Endometriosis on Women’s Daily Functioning, Emotional Well-Being, and Quality of Life: A Cross-Sectional Study 2026
- Illness Invalidation and Demoralization in Endometriosis: Does Self-Compassion Help? 2025
- Directive clinique no 449 : Directive canadienne sur le diagnostic et les impacts de l’endométriose 2024
- Guideline No. 449: Diagnosis and Impact of Endometriosis - A Canadian Guideline 2024
- Psychosocial correlates of symptoms of depression among patients with endometriosis in the United Kingdom 2022
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