Precision Medical Management of Endometriosis: Neuroimmune Pathophysiology, Pain Phenotyping and Emerging Target Therapies

Perla Sofía Vera Hernández, Sofia Hernandez Vega, Ramiro Cabrera Carranco, Ramiro Cabrera, Ana Gabriela Sierra Brozón, William Kondo, Jordanna Diniz Osaki, Fernando Heredia Muñoz, Lucia Chaul and Christian Silva Rengifo
In: Endometriosis - Medical Aspects and Modern Approaches [Working Title] · 2026 · doi:10.5772/intechopen.1014711 · W7133493437
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This chapter integrates neuroimmune pathophysiology, pain phenotyping, and emerging therapies to guide precision medical management of endometriosis beyond traditional hormonal suppression.

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Abstract

Endometriosis is a chronic, estrogen-dependent inflammatory disease influenced by complex neuroimmune interactions and pain chronification mechanisms. Modern medical management is increasingly guided by a deeper understanding of neuroinflammation, peripheral and central sensitization, and immune dysregulation, moving beyond traditional hormonal suppression. This chapter will synthesize the latest evidence on precision medicine approaches, integrating pain phenotyping, molecular and inflammatory biomarkers, and mechanisms of treatment resistance. It will explore targeted pharmacologic strategies, including neuromodulators, selective progesterone receptor modulators, immunomodulatory and anti-fibrotic agents, as well as innovative non-hormonal therapies under investigation. Additionally, it will highlight research gaps and opportunities for translational applications. The aim is to provide a rigorous, mechanism-based framework for individualized, effective, and biologically informed medical treatment of endometriosis.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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last seen: 2026-06-10T17:14:06.276822+00:00
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