Fertility outcome after laparoscopic treatment of advanced endometriosis in two groups of infertile patients with and without ovarian endometrioma

Adel Shervin, Shervin A, Arash Mohazzab, Aminlou M, Mina Aminlou, Koorosh Kamali, Roya Padmehr, Padmehr R, Khadijeh Shadjoo, Shadjoo K, Jaberi-Pour P, Parvin Jaberi-Pour, Akbari E, Elham Akbari
European journal of obstetrics, gynecology, and reproductive biology · 2016 · vol. 201 , pp. 46–50 · doi:10.1016/j.ejogrb.2016.03.009 · PMID:27054965 · W2293955664
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This study investigated pregnancy rates following laparoscopic surgery for advanced endometriosis in infertile patients, comparing outcomes between those with and without ovarian endometriomas.

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Abstract

OBJECTIVE: To evaluate the result of laparoscopic endometrioma excision in fertility outcome of advanced endometriosis patients. STUDY DESIGN: The study was designated as historical cohort, in a private referral center of advance laparoscopy. 111 infertile patients, diagnosed as endometriosis, were divided in two groups: DIE (deep infiltrative endometriosis) and endometrioma (case group), and patients with only DIE (without endometrioma ((control group). All patients underwent global laparoscopic resection of DIE lesion (both groups) and laparoscopic excisional cystectomy of endometrioma (case groups). Patients were followed for fertility outcomes and data were analyzed by Kaplan-Meier test and COX regression using SPSS software. RESULTS: After adjusting covariates, the Kaplan-Meier analysis of cumulative pregnancy rates (CPR) did not show any statistical significance between cases (35.6%) and controls (39.5%) (Log-rank P-value=0.959). The COX regression analysis of covariates showed there is no significant relationship between cystectomy and fertility outcome. It showed statistical significance effect of age (hazard ratio [HR]=0.772), years of infertility (HR=0.224), and previous endometrioma surgery (HR=0.180), on fertility chance. CONCLUSION: In advanced endometriosis with DIE and infertility, fine excision and stripping of the endometrioma along with radical resection of DIE improves fecundity without any significant adverse effect in comparison with patients with intact ovaries.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Gynecologic Surgical Procedures Gynecologic Surgical Procedures Infertility, Female Ovarian Diseases Adult Adult Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Laparoscopy Laparoscopy Ovarian Diseases Ovarian Diseases Pregnancy

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Cited by (10)

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