Die Behandlung der Endometriose mit einem langwirksamen, injizierbaren LH-RH-Analogon (Buserelin)

Inka Wiegratz, M. Dannhof, R. Baumann, H.‐D. Taubert
In: Gynäkologie und Geburtshilfe 1992 · 1993 · pp. 592–594 · doi:10.1007/978-3-642-77857-5_220 · W1964074057
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-14 ⓘ

This paper discusses the estrogen-dependent nature of endometriosis and the established GnRH analog treatment principle, suggesting a need for a long-acting implantable drug for this condition.

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The paper discusses the treatment of endometriosis using long-acting injectable GnRH (LH-RH) analog buserelin, motivated by the view that endometriosis is estrogen-dependent and can be suppressed by states of low estradiol such as menopause. It frames GnRH-analog therapy as an established principle typically administered for about 6 months, and proposes that an ideal approach would be a single application delivering drug exposure for the full intended duration. A key caveat is that the paper notes the etiology and pathogenesis of endometriosis are not yet fully understood, which limits certainty about upstream mechanisms despite the hormonal rationale. This paper is centrally about endometriosis — specifically the use of long-acting injectable buserelin as a GnRH-analog treatment concept.

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Zusammenfassung Die Endometriose ist eine häufige Erkrankung geschlechtsreifer Frauen (1). Die Ätiologie und Pathogenese sind bis heute noch nicht abschließend geklärt. Fest steht jedoch, daß die Endometriose östrogenabhängig ist und eine Östradiol-Mangel wie z.B. in der Postmenopause zum Sistieren der Erkrankung führt. Die Behandlung der Endometriose mit Gonadotropin-Releasing Hormon-(GnRH-) Analoga stellt ein inzwischen bewährtes Behandlungsprinzip dar. Die Therapie wird im allgemeinen für die Dauer von 6 Monaten durchgeführt. Idealerweise könnte man den Patientinnen einmalig ein Wirkstoffimplantat applizieren, welches exakt für diesen Zeitraum wirksam wäre. Similar content being viewed by others Literatur Barbieri, R.L.: Etiology and epidemiology of endometriosis Am. J. Obstet. Gynecol. 162, 565–567, 1990 Buttram, V.C.Jr.: Evolution of the Revised American Fertility Society Classification of Endometriosis Fertil Steril 43, 347–350, 1985 Evers, J.L.H.: The second-look laparoscopy for evaluation of the result of medical treatment of endometriosis should not be performed during ovarian suppression Fertil Steril 47, 502–504, 1987 Brown, J.B.: Gonadotropins In: Infertility. Male and Female, p. 359, Insler, V., Lunenfeld, B. (eds) Edinburgh, Churchill Livindston 1986 Fraser, H.M., Sandow, J., Seidel, H., v.Rechenberg, W.: An implant of agonadotropin releasing hormone agonist (buserelin) which suppresses ovarian function in the macaque for 3–5 month Acta Endocrinol (Copenh) 115, 521–527, 1987 Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 1993 Springer-Verlag Berlin Heidelberg About this paper Cite this paper Wiegratz, I., Dannhof, M., Baumann, R., Taubert, HD. (1993). Die Behandlung der Endometriose mit einem langwirksamen, injizierbaren LH-RH-Analogon (Buserelin). In: Krebs, D., Berg, D. (eds) Gynäkologie und Geburtshilfe 1992. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77857-5_220 Download citation DOI: https://doi.org/10.1007/978-3-642-77857-5_220 Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-642-77858-2 Online ISBN: 978-3-642-77857-5 eBook Packages: Springer Book Archive

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