Clinical analyses of endometriosis after conservative surgery.
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This study analyzed 199 moderate-to-severe endometriosis patients, finding surgery improved remission and fertility, with GnRH-α showing the lowest recurrence rate compared to surgery alone or mifepristone.
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Abstract
OBJECTIVE: To assess the remission rate and outcome of pregnancy of patients who had moderate and severe ovarian endometriosis after conservative surgery. We also wished to analyze the associated factors of recurrence. METHODS: Weconducted retrospective analyses of 199 cases with stage II-IV ovarian endometriosis who had preserved fertility under laparoscopic surgical treatment. Postoperatively, the 199 patients were divided into three groups: 43 cases underwent surgical treatment alone (group A); 47 were given a gonadotropin-releasing hormone agonist (GnRH-α) (group B), and 109 were given mifepristone (group C). Ten cases in group A were infertile, 26 cases in group B, and 38 cases in group C. All patients were followed up for 3 years. This study was approved by the Ethics Committee of Yangpu District Central Hospital. RESULTS: In groups A, B and C, the remission rate was 58.13%, 70.21% and 60.55% and the difference not significant (P=0.384); Recurrence rates were 27.90%, 12.76% and 24.77%, and the difference between them significant (P<0.05). The recurrence rate in group B was the lowest. The natural pregnancy rate after surgery in the three study groups (untreated, GnRH-α and mifepristone) was 30%, 34.61% and 28.94% but this difference was not significant. CONCLUSION: Surgery can improve the symptom remission rate and fertility of patients. Postoperative drug therapy does not improve the chance of pregnancy.
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References (10)
- A randomized study comparing triptorelin or expectant management following conservative laparoscopic surgery for symptomatic stage III–IV endometriosis via openalex
- Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis via openalex
- Laparoscopic surgery for subfertility associated with endometriosis via openalex
- Management of the Pain Associated with Endometriosis: An Update of the Painful Problems via openalex
- Recurrence of ovarian endometrioma after laparoscopic excision: Risk factors and prevention via openalex
- RU486-induced growth inhibition of human endometrial cells via openalex
- The effectiveness of laparoscopic excision of endometriosis via openalex
- [The therapy of endometriosis. New prospects]. via openalex
- W2074799394 via openalex
- W2141674141 via openalex
Cited by (4)
- Reproductive capacity and recurrence of disease after surgery for moderate and severe endometriosis – a retrospective single center analysis 2020
- Reproductive capacity and recurrence of disease after surgery for moderate and severe endometriosis – a retrospective single center analysis 2020
- Reproductive capacity and recurrence of disease after surgery for moderate and severe endometriosis. 2020
- Endometriosis: When and How We Treat 2017
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:21:13.485820+00:00
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