Sonoelastography in differential diagnosis of pathological processes of the myometrium (literature review)

In: Український радіологічний та онкологічний журнал · 2021 · vol. 29(2) , pp. 108–126 · doi:10.46879/ukroj.2.2021.108-126 · W3184962977
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AI-generated summary by gemini-2.5-flash-lite, 2026-06-07

This review analyzes literature on sonoelastography for differentiating myometrial pathologies like leiomyoma, adenomyosis, and adenocarcinoma, finding it improves diagnostic accuracy when combined with B-mode sonography.

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This paper is a literature review that systematically analyzes 2013–2020 English-language studies on imaging methods for diagnosing pathological processes of the uterus, focusing on sonoelastography and its use alongside other ultrasound approaches to differentiate myometrial disorders such as leiomyoma, adenomyosis, and infiltrative adenocarcinoma. Across the reviewed literature, the authors report that adding sonoelastography data to conventional gray-scale ultrasonography can improve differential diagnosis of leiomyoma, adenomyosis, and normal myometrium, increasing diagnostic accuracy and concordance, while the method is described as potentially more safe and accessible. A key limitation emphasized is the limited number of studies and the lack of general standards for sonoelastography technique and interpretation in reproductive-system pathology. This paper is centrally about endometriosis and adenomyosis — specifically adenomyosis-focused myometrial differential diagnosis using sonoelastography.

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Abstract

Background. Intrauterine pathological processes, the most common medical conditions of which are leiomyoma, adenomyosis and infiltrative adenocarci- noma, currently represent a quite prevailing group of gynecological pathology, dangerous due to the potential of malignancy and recurrence. The development of an integrated non-invasive diagnostic approach that takes into account risk factors, symptoms, clinical examination and imaging, makes it possible to make an accurate diagnosis, which is essential to determine therapeutic strategy. Рurpose – to carry out a systematic analysis of the uptodate scientific literature regarding the use of imaging methods in diagnosis of pathological processes of the myometrium and determine the main directions of their development in these pathologies. Materials and methods. The material for the study were publications and results of clinical trials found in Scopus, Web of Science Core Collection and PubMed databases for the period from 2013 to 2020 based on the keywords like “adeno- myosis”, “leiomyoma”, “adenocarcinoma”, “sonography”, “sonoelastography”. Results and discussion. The complexity of diagnosing myometrial neoplasms, especially in case of combinations, initiates the search for new algorithms for diagnosing pathological processes of the myometrium, the purpose of which, ultimately, is to determine personalized strategy of treatment of female patients. According to the literature, recently sonoelastography potential has been increasingly used in diagnosis of the reproductive system diseases and assessment of the functional state of uterine tissues, contributing to differential diagnosis, monitoring and treatment of these diseases. Conclusions. Thus, there is a limited number of studies on the diagnosis of myometrium pathology along with insufficient general standards of technique for conducting and interpreting the findings of sonoelastography in the reproductive system pathology. Adding sonoelastography data to sonographic images in B-mode is useful for differentiating leiomyoma, adenomyosis, and normal uterus, which is reflected in increased accuracy and diagnostic consistency. Sonoelastography potential consists in increasing the accuracy of diagnosis, safety and availability of the method, its low cost. This contributes to the possibility of wider implementation of the technique in clinical practice in order to obtain additional diagnostic information.
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Анотація Актуальність. Внутрішньоматкові патологічні процеси, найпоширені- шими нозологіями яких є лейоміома, аденоміоз та інфільтративна форма аденокарциноми, нині являють досить розповсюджену групу гінеколо- гічної патології, небезпечну через можливість злоякісності та рецидиву- вання. Розроблення інтегрованого неінвазивного діагностичного підходу, який бере до уваги чинники ризику, симптоми, клінічне обстеження та візуалізацію, створює можливість встановлення точного діагнозу для визначення терапевтичної тактики. Мета роботи – провести систематичний аналіз сучасної наукової літера- тури щодо застосування методів візуалізації в діагностиці патологічних процесів матки та визначити основні напрямки їхнього розвитку при зазначених патологіях. Матеріали та методи. Було проаналізовано і систематизовано дані повно- текстових публікацій у закордонних (англомовних) наукових виданнях за період 2013–2020 рр., відібраних шляхом пошуку в базах даних Scopus, Web of Science Core Collection і PubMed за ключовими словами «adenomy- osis», «leiomyoma», «adenocarcinoma», «sonography», «sonoelastography». Результати та їх обговорення. Складність діагностики новоутворень міометрія, особливо їхньої сполученості, спрямовує на пошук нових алгоритмів діагностики патологічних процесів міометрія, метою чого, у кінцевому рахунку, є визначення персоніфікованої тактики лікування хворих жінок. За даними літератури, останнім часом усе частіше застосовують можливості соноеластографії в діагностиці хвороб репродуктивної системи та оцінюванні стану тканин матки, що сприяє диференційній діагностиці, моніторингу та лікуванню зазначених захворювань. Висновки. На сьогодні зазначається обмежена кількість досліджень щодо питань діагностики патології матки та брак загальних стандартів техніки проведення та інтерпретації отриманих результатів соноеластографії при патології репродуктивної системи. Додавання даних соноеластографії до сірошкальних діагностичних зображень є корисним для диференціації лейоміоми, аденоміозу та нормальної матки, що відбивається у підвищенні точності та діагностичній узгодженості. Перспективність соноеластографії полягає в підвищенні точності діагностики, безпечності та доступності методу, невеликій вартості. Це сприяє можливості більш широкого впровадження методу в клінічну практику з метою отримання додаткової діагностичної інформації. Посилання Stewart EA, Laughlin-Tommaso SK, Catherino WH, Lalitkumar S, Gupta D, Vollenhoven B. Uterine fibroids. Nature reviews. Disease primers. 2016;2:16043. (In English). DOI: https://doi.org/10.1038/nrdp.2016.43 Sparic R, Mirkovic L, Malvasi A, Tinelli A. 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