Exploring the pain and substance use in endometriosis: A transactional model investigation with a focus on cannabinoids and opioids

Guillaume Broc, Margaux Le Borgne, Anthony Gauduchon, Émeline Chauchard
In: Journal of Endometriosis and Pelvic Pain Disorders · 2026 · doi:10.1177/22840265261438172 · W7160277333
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This study investigated the transactional relationship between endometriosis pain, substance use (cannabinoids and opioids), and pain-related anxiety, finding that substance use predicted pain intensity, which in turn influenced pain-related anxiety and subsequent substance use.

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The provided text consists solely of metadata, access options, and publication details for an article titled "Exploring the pain and substance use in endometriosis: A transactional model investigation with a focus on cannabinoids and opioids." It lacks the abstract, methods, results, or full body text necessary to summarize the study's actual content, population, or findings. Consequently, no substantive scientific conclusions can be drawn from the available information regarding the relationship between pain, substance use, or cannabinoids in this context. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Purpose: This study aimed to investigate the reciprocal relationship between endometriosis-related pain and the consumption of cannabinoids and opioids. Additionally, this study explores whether pain-related anxiety acts as a mediator in this relationship by adopting a transactional model of adaptation to endometriosis. Methods: This cross-sectional study included 334 adult women diagnosed with endometriosis. An online questionnaire, distributed through social networks and patient associations, gathered data on pain intensity, substance use (cannabis, CBD, and opioids), pain-related anxiety, distress tolerance, and anxiety sensitivity. Results: Descriptive statistics revealed that 74.25% of participants reported using at least one substance. Pain was positively correlated with the severity level of CBD, opioid use, and pain-related anxiety. The severity level of cannabis uses negatively correlated with distress tolerance. Path modeling demonstrated that substance use predicted pain intensity, and that pain intensity is associated with pain-related anxiety, subsequently influencing substance use. The model suggests a transactional relationship between pain, pain-related anxiety, and substance use. Conclusions: These findings underscore the need for tailored therapeutic approaches for women with endometriosis. Substance use is associated with increased pain intensity, indicating a complex interplay. This study highlights the importance of considering psychosocial factors such as pain-related anxiety in understanding the relationship between substance use and pain in endometriosis. A comprehensive approach to care involving both medical and psychological perspectives is essential. Further studies are also required.
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Data availability statement Authors Author contributions Metrics and citations Metrics Journals metrics This article was published in Journal of Endometriosis and Pelvic Pain Disorders. View All Journal MetricsPublication usage* Total views and downloads: 4 *Publication usage tracking started in December 2016 Publications citing this one Receive email alerts when this publication is cited Web of Science: 0 Crossref: There are no citing articles to show. Figures and tables Figures & Media Tables View Options Access options If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below: loading institutional access options Alternatively, view purchase options below: Purchase 24 hour online access to view and download content. Access journal content via a DeepDyve subscription or find out more about this option.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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