Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis

Nalinda Silva, Kamani Hemamala Tennekoon, Kamani Tennekoon, Hemantha Senanayake, Sameera R. Samarakoon, Sameera Samarakoon
Taiwanese journal of obstetrics & gynecology · 2013 · vol. 52(4) , pp. 540–545 · doi:10.1016/j.tjog.2013.10.015 · PMID:24411040 · W1990373589
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Metalloestrogen cadmium stimulated stromal cell proliferation from the eutopic endometrium of women with endometriosis more than from women without endometriosis.

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Abstract

OBJECTIVE: To assess the effect of metalloestrogen cadmium (Cd) on the proliferation of endometrial stromal cells (ESC) isolated from the eutopic endometrium of women with endometriosis MATERIALS AND METHODS: ESC were isolated from eutopic endometrial samples from 10 women with endometriosis and 10 women without endometriosis. ESC cultures were established and maintained in RPMI medium. Cultures were treated with Cd at a concentration of 10(-6) M and after 24 hours and 48 hours, cell number was counted using the Neubauer hemocytometer to calculate the relative cell proliferation. At 48 hours, the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay was used to test the effect of different concentrations (10(-8) M to 10(-3) M) of Cd on ESC cultures. Relative cell proliferation and MTT assay results were analyzed with ANOVA. RESULTS: At 48 hours, Cd-induced ESC proliferation was higher (p = 0.02) in women with endometriosis than in women without endometriosis, which was confirmed by the MTT assay. CONCLUSION: The results of this study demonstrate the ability of metalloestrogen Cd to induce the proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cadmium Cell Proliferation Cell Survival Endometriosis Endometrium Stromal Cells Cadmium Case-Control Studies Cell Proliferation Cells, Cultured Cell Survival Endometriosis Endometrium Estrogens Female Humans Organometallic Compounds Stromal Cells

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