Isolation of myeloid-derived suppressor cells (MDSC) from endometriotic mice model and their immunomodulatory functions

Song Y, Yi Song, Yingyu Liu, Liu Y, Xu Q, Qianhan Xu, Kam Tong Leung, Loucia Kit Ying Chan, Chan LKY, Jacqueline Pui Wah Chung, Chung JPW, Chi Chiu Wang, Wang CC, Chen X, Xiaoyan Chen, Tao Zhang, Gene Chi Wai Man
Methods in cell biology · 2023 · vol. 184 , pp. 33–57 · doi:10.1016/bs.mcb.2023.04.004 · PMID:38555157 · W4387788468
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This study isolated myeloid-derived suppressor cells (MDSCs) from an established mouse model of endometriosis to characterize their immunomodulatory functions within the disease microenvironment.

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Abstract

Endometriosis is a chronic, painful disease whose etiology remains unknown. The development of novel therapies and diagnostic tools for endometriosis has been limited due in part to challenges in studying the disease. Recently, a few reports have shown that immunosuppressive cells, such as myeloid-derived suppressor cell (MDSC), may promote the progression of endometriosis. MDSCs are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, in this chapter, we provide a detailed protocol to phenotype MDSC as well as to isolate and assess the functionality from the peritoneal cavity of a mouse model of surgically induced endometriosis. Importantly, the current mouse model has been widely used to study how the immune system, hormones, and environmental factors affect endometriosis as well as the effects of endometriosis on fertility and pain.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

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