Intravascular Endometrium Mimicking Vascular Invasion
Case report
OA: closed
CC0
AI-generated summary
This paper describes a case of intravascular endometrium, confirmed by histology and immunohistochemistry, that mimicked vascular invasion in a patient with cervical adenocarcinoma.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Intravascular endometrium (IEM) is a rare finding that can pose a significant diagnostic dilemma, especially in cases of known carcinoma where the possibility of vascular invasion must be entertained. The distinction between IEM and intravascular invasion of malignancy can be made based on histologic findings and immunohistochemical profile. We report a case of IEM in a hysterectomy specimen removed from a 38 year old patient with invasive cervical adenocarcinoma and adenomyosis. Histologically, the lumen and intima of large muscular vessels contained well-developed glands with high nuclear to cytoplasmic ratio and endometrial stroma with spindled nuclei associated with hemorrhage and hemosiderin-laden macrophages. By immunohistochemistry, the benign glands within vascular spaces were positive for vimentin, ER and PR, but only rare cells were positive for p16. The stroma surrounding the intravascular glands was positive for CD10. These results confirmed the presence of IEM. The presence of IEM may be confused with vascular invasion which may affect staging and treatment of the patient.
My notes (saved in your browser only)
Condition tags
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (12)
- CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma via openalex
- Endometrial tissue in myometrial vessels not associated with menstruation via openalex
- Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia via openalex
- Intravascular endometriosis with thrombosis in a patient with adenomyosis via openalex
- Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation via openalex
- Observations on the pathology and spread of endometriosis based on the theory of benign metastasis via openalex
- W1968277161 via openalex
- W1994591004 via openalex
- W2149350357 via openalex
- W2317306212 via openalex
- W2139753458 via openalex
- W2023491780 via openalex
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- unpaywall
- last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0
· commercial use OK