Expression of human endogenous gammaretroviral sequences in endometriosis and ovarian cancer

Lijuan Hu, Hu L, Hornung D, Daniela Hornung, Raffael Kurek, Kurek R, Helen Ostman, Ostman H, Helen Östman, Jonas Blomberg, Agneta Bergqvist, Bergqvist A
AIDS research and human retroviruses · 2006 · vol. 22(6) , pp. 551–557 · doi:10.1089/aid.2006.22.551 · PMID:16796530 · W1991840700
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This study found significantly higher HERV-E RNA expression in endometriotic tissue compared to normal endometrium, and distinct HERV-E and HERV-W expression patterns in normal versus cancerous ovarian tissue.

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Abstract

Endogenous retroviruses (ERVs) probably originate from ancient germ cell infections by exogenous retroviruses. A high expression of retroviruses in reproductive tissue increases the risk of viral transmission to germ line cells. We therefore investigated the expression of human ERVs (HERVs) in normal endometrium, endometriosis, normal ovaries, and ovarian cancer. Four real-time PCRs (QPCRs) for HERV-E, HERV-I/T, HERV-H, and HERV-W, respectively, and an expression control gene were used. HERV-E RNA expression was significantly higher in endometriotic tissue (average, SD) than in normal endometrium (average, SD), both measured as ratios versus control gene expression and as. HERV-E and HERV-W RNA were higher in normal ovarian tissue than in ovarian cancer. This illustrates that HERV expression is not automatically higher in malignant tissues. The other HERV PCRs did not show expression patterns as distinctive as HERVE and HERV-W in the two kinds of reproductive tissue. A small number of candidate HERV-E loci from which the transcription took place were identified by sequencing of amplimers. The role of HERV-E and HERV-W in endometriosis merits further investigation.

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Condition tags

endometriosis

MeSH descriptors

Endogenous Retroviruses Endometriosis Gammaretrovirus Ovarian Neoplasms Base Sequence Base Sequence Cloning, Molecular Cloning, Molecular Endogenous Retroviruses Endogenous Retroviruses Endogenous Retroviruses Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Gammaretrovirus Gammaretrovirus

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (44)

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