Photodegradation kinetic study and stability-indicating assay of danazol using high-performance liquid chromatography
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A HPLC method was developed to quantify danazol and its photolytic degradation products formed under UV irradiation, determining kinetic parameters of the degradation process.
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Abstract
A selective high-performance liquid chromatographic procedure for the stability-indicating determination of danazol in the presence of its photolytic degradation products is demonstrated. The photolysis was carried out in glass vials and quartz cell under UV light at 254 nm. Satisfactory results were obtained for the assay and recovery testing with RSD values less than 2%. Kinetic parameters evaluated comprise the order of reaction and the rate constants of the degradation of the danazol irradiated in glass vials or quartz cell.
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References (9)
- Analysis of danazol in serum using high-performance liquid chromatography via openalex
- Determination of danazol in pharmaceutical preparations by liquid chromatography via openalex
- Determination of Danazol in Plasma by High Performance Liquid Chromatography via openalex
- Sensitive and selective assay of danazol in plasma by high-performance liquid chromatography via openalex
- doi:10.1002/9780470508183 via openalex
- doi:10.1016/0378-5173(79)90032-2 via openalex
- W599430137 via openalex
- W4285719527 via openalex
- doi:10.1093/chromsci/28.4.162 via openalex
Cited by (6)
- Danazol 2022
- Miniaturized ionic liquid dispersive liquid-liquid microextraction in a coupled-syringe system combined with UV for extraction and determination of danazol in danazol capsule and mice serum 2016
- Development and validation of TLC-densitometric method for the quantification of a steroidal drug, danazol in its pharmaceutical formulations 2012
- Square-wave adsorptive stripping voltammetric determination of danazol in capsules 2006
- Voltammetric study of danazol and its determination in capsules and spiked biological fluids 2004
- Conventional and micellar liquid chromatography method development for danazol and validation in capsules 2003
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- openalex
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- pubmed
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- unpaywall
- last seen: 2026-10-19T06:34:38.229974+00:00
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