Photodegradation kinetic study and stability-indicating assay of danazol using high-performance liquid chromatography

El-Rasheed A. Gad Kariem, Mohammed Abounassif, M. E. M. Hagga, Hamad A. Al‐Khamees
In: Journal of Pharmaceutical and Biomedical Analysis · 2000 · vol. 23(2-3) , pp. 413–420 · doi:10.1016/s0731-7085(00)00315-0 · PMID:10933534 · W1991861646
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A HPLC method was developed to quantify danazol and its photolytic degradation products formed under UV irradiation, determining kinetic parameters of the degradation process.

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Abstract

A selective high-performance liquid chromatographic procedure for the stability-indicating determination of danazol in the presence of its photolytic degradation products is demonstrated. The photolysis was carried out in glass vials and quartz cell under UV light at 254 nm. Satisfactory results were obtained for the assay and recovery testing with RSD values less than 2%. Kinetic parameters evaluated comprise the order of reaction and the rate constants of the degradation of the danazol irradiated in glass vials or quartz cell.

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