Mean Platelet Volume Increase in Endometriomas and Benign Ovarian Cysts: A Prospective Case-Controlled Study

Metin Kaba, Aysegul Oksuz glu, Ömer Ant, Bekir Serdar Ünlü, Eren Akbaba, Hakan Tımur, Gülnur Özakşit
In: Medical Science and Discovery · 2021 · vol. 8(6) , pp. 361–365 · doi:10.36472/msd.v8i6.549 · W3176452727
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Mean platelet volume was increased in women with ovarian endometriomas and benign cysts, showing predictive value for both conditions compared to an infertile control group.

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This prospective case-control study compared mean platelet volume (MPV) measured from complete blood counts in women with surgically confirmed ovarian endometriomas, women with benign ovarian cysts, and infertile healthy controls (n=98, 94, and 99, respectively). MPV differed significantly among groups (p<0.01), and MPV was statistically similar between the endometrioma and benign cyst groups but different from the infertile control group; MPV also showed moderate discrimination with reported areas under the curve (~0.72–0.73) and sensitivities/specificities around the low-to-mid 70%/60% range at a cut-off of 9.05 fl. A key limitation explicitly implied by the design is that MPV increases were assessed at one time point in a histology-confirmed surgical population, which may not generalize to all clinical settings or timing of blood sampling. This paper is centrally about endometriosis — it evaluates whether mean platelet volume is increased in women with ovarian endometriomas and estimates its predictive performance relative to benign cysts.

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Abstract

Objective: The aim of this research is to compare mean platelet volumes (MPV) among women with ovarian endometriomas, women with benign ovarian cysts and infertile women who were otherwise healthy. Material and Methods: Women were selected for the ovarian endometrioma and benign ovarian cyst group after laparoscopic ovarian cyst excision and confirmed histopathologic evaluation. The control group was assigned from women with male partner infertility or unexplained infertility but who were otherwise healthy. Mean platelet volume calculated as a part of complete blood count, which collected in potassium ethylenediaminetetraacetic acid tubes Results: There were 98 women in the endometrioma group, 94 in the benign cyst group and 99 in the control group. Mean platelet volume was different among the groups (p<0.01). The mean platelet volume in the infertile group was statistically different than in the endometrioma and benign cyst groups and was similar between the endometrioma and benign cyst groups. When compared with the infertile group, the area under the curve and predictive value of the mean platelet volume for the endometrioma and the benign cyst group were 0.73 ±0.03 fl (p<0.01, CI 0.65-0.80) and 0.72±0.06 fl (p<0.01; CI 0.64-0.79), respectively. Mean platelet volume had a sensitivity of 74% and specificity of 63% for endometrioma and sensitivity of 72%, and specificity of 63% for benign cysts at a cut-off point of 9.05 fl. Conclusion: The present study demonstrated that mean platelet volume was increased in women with ovarian endometriomas and benign cysts and showed predictive values for endometriomas and benign ovarian cysts.
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Abstract

Objective: The aim of this research is to compare mean platelet volumes (MPV) among women with ovarian endometriomas, women with benign ovarian cysts and infertile women who were otherwise healthy.

Material and methods

Women were selected for the ovarian endometrioma and benign ovarian cyst group after laparoscopic ovarian cyst excision and confirmed histopathologic evaluation. The control group was assigned from women with male partner infertility or unexplained infertility but who were otherwise healthy. Mean platelet volume calculated as a part of complete blood count, which collected in potassium ethylenediaminetetraacetic acid tubes

Results

There were 98 women in the endometrioma group, 94 in the benign cyst group and 99 in the control group. Mean platelet volume was different among the groups (p<0.01). The mean platelet volume in the infertile group was statistically different than in the endometrioma and benign cyst groups and was similar between the endometrioma and benign cyst groups. When compared with the infertile group, the area under the curve and predictive value of the mean platelet volume for the endometrioma and the benign cyst group were 0.73 ±0.03 fl (p<0.01, CI 0.65-0.80) and 0.72±0.06 fl (p<0.01; CI 0.64-0.79), respectively. Mean platelet volume had a sensitivity of 74% and specificity of 63% for endometrioma and sensitivity of 72%, and specificity of 63% for benign cysts at a cut-off point of 9.05 fl.

Conclusion

The present study demonstrated that mean platelet volume was increased in women with ovarian endometriomas and benign cysts and showed predictive values for endometriomas and benign ovarian cysts. Downloads Article Details This journal uses the Creative Commons Attribution 4.0 International License (CC BY 4.0). Under this license, users are free to: - Share — copy and redistribute the material in any medium or format - Adapt — remix, transform, and build upon the material for any purpose, even commercially Under the following terms: - Attribution — appropriate credit must be given, a link to the license must be provided, and changes (if any) must be indicated. License URL: https://creativecommons.org/licenses/by/4.0/ Accepted 2021-06-16 Published 2021-06-29 - Abstract 2841 - Full Text (PDF) 0

References

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