Could hematologic parameters be useful biomarkers for the diagnosis of endometriosis?

Ali Turgut, A Turgut, Turgut A, Meryem Hocaoğlu, Hocaoglu M, M. Hocaoglu, Özkan Özdamar, O Ozdamar, Ozdamar O, Merve Usta, A Usta, Usta A, Gunay T, T Gunay, Türkan Günay, Esra Akdenız, E Akdeniz
Bratislavske lekarske listy · 2019 · vol. 120(12) , pp. 912–918 · doi:10.4149/bll_2019_153 · PMID:31855050 · W2994637594
article OA: diamond CC0 ⤵ 9 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This retrospective study found that higher neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV), along with lower lymphocyte-to-monocyte ratio (LMR), can distinguish women with endometriosis from controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This retrospective study evaluated whether hematologic parameters—neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and mean platelet volume (MPV)—could distinguish 121 women with endometriosis from 136 healthy controls, using receiver-operating characteristic analyses and disease staging by the revised American Society for Reproductive Medicine classification. Compared with controls, the endometriosis group had higher neutrophil counts, white blood cell levels, NLR, and MPV, and lower lymphocyte counts and LMR, with proposed cut-offs including NLR ≥1.6 (87.6% sensitivity, 44.8% specificity) and MPV ≥8 (75.2% sensitivity, 68.4% specificity). LMR and MPV were lower in stages III–IV than stages I–II. The paper’s main limitation is that it is retrospective, and it does not report any validation in an independent cohort. This paper is centrally about endometriosis—assessing NLR, LMR, and MPV as potential non-invasive diagnostic biomarkers.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

OBJECTIVES: The objective of this study was to evaluate the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte‑to‑monocyte ratio (LMR), and mean platelet volume (MPV) in patients with endometriosis as compared with healthy controls. BACKGROUND: Currently, no non-invasive diagnostic test of endometriosis has been implemented in clinical practice. METHODS: A total of 121 women with endometriosis and 136 controls participated in this retrospective study. The extent of the disease in the patients with endometriosis was determined using the American Society of Reproductive Medicine revised classification. Sensitivities and specificities of NLR, LMR and MPV were evaluated by receiver-operating characteristic (ROC) analysis. RESULTS: Patients with endometriosis had higher neutrophil counts, white blood cell (WBC) levels, NLR, MPV, and lower lymphocyte count and LMR than the control group. The cut-off values were found to be 1.6 for NLR at 87.6 % sensitivity and 44.8 % specificity and 8 for MPV at 75.2 % sensitivity and 68.4 % specficity. For LMR, the cut-off value was 5.6 with 66.1 % sensitivity, 50 % specificity. Patients with stages III or IV had significantly lower MPV (p = 0.039) and LMR levels (p = 0.016) than patients with stages I or II. CONCLUSION: NLR, LMR, and MPV may be used to distinguish patients with endometriosis from controls (Tab. 4, Fig. 4, Ref. 37).
Full text 2,342 characters · extracted from oa-doi-fallback · click to expand
Journal info | |||| Select Journal Journals Bratislava Medical Journal 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Ekologia - Ecology Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudba 2025Webshop Cart Your Cart is currently empty. Bratislava Medical Journal Vol.120, No.12, p.912–918, 2019 | || | Title: Could hematologic parameters be useful biomarkers for the diagnosis of endometriosis? | || | Author: A. Turgut, M. Hocaoglu, O. Ozdamar, A. Usta, T. Gunay, E. Akdeniz | || | Abstract: OBJECTIVES: The objective of this study was to evaluate the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte‑to‑monocyte ratio (LMR), and mean platelet volume (MPV) in patients with endometriosis as compared with healthy controls. BACKGROUND: Currently, no non-invasive diagnostic test of endometriosis has been implemented in clinical practice. METHODS: A total of 121 women with endometriosis and 136 controls participated in this retrospective study. The extent of the disease in the patients with endometriosis was determined using the American Society of Reproductive Medicine revised classification. Sensitivities and specificities of NLR, LMR and MPV were evaluated by receiver-operating characteristic (ROC) analysis. RESULTS: Patients with endometriosis had higher neutrophil counts, white blood cell (WBC) levels, NLR, MPV, and lower lymphocyte count and LMR than the control group. The cut-off values were found to be 1.6 for NLR at 87.6 % sensitivity and 44.8 % specificity and 8 for MPV at 75.2 % sensitivity and 68.4 % specficity. For LMR, the cut-off value was 5.6 with 66.1 % sensitivity, 50 % specificity. Patients with stages III or IV had significantly lower MPV (p = 0.039) and LMR levels (p = 0.016) than patients with stages I or II. CONCLUSION: NLR, LMR, and MPV may be used to distinguish patients with endometriosis from controls (Tab. 4, Fig. 4, Ref. 37). | || | Keywords: CA-125, endometriosis, lymphocyte‑to‑monocyte ratio, mean platelet volume, neutrophil‑to‑lymphocyte ratio | || | Published online: 18-Dec-2019 | || | Year: 2019, Volume: 120, Issue: 12 | Page From: 912, Page To: 918 | | | doi:10.4149/BLL_2019_153 | || | | download file | |

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Biomarkers, Tumor CA-125 Antigen Endometriosis Lymphocyte Count Mean Platelet Volume Biomarkers, Tumor CA-125 Antigen Case-Control Studies Endometriosis Endometriosis Endometriosis Female Humans Lymphocytes Neutrophils Retrospective Studies Sensitivity and Specificity

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (10)

Source provenance

europepmc
last seen: 2026-08-16T09:21:09.727480+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:22:22.912744+00:00
License: CC0 · commercial use OK