Danazol suspension injected into the uterine cervix of patients with adenomyosis and myoma. Preliminary study

Takebayashi T, T. Takebayashi, Fujino Y, Y Fujino, Yuji Fujino, N Umesaki, Naohiko Umesaki, Umesaki N, S Ogita, Ogita S, Sachio Ogita
Gynecologic and obstetric investigation · 2010 · vol. 39(3) , pp. 207–211 · doi:10.1159/000292410 · PMID:7789919 · W2044508577
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Danazol suspension injected into the uterine cervix achieved high concentrations in cervical and endometrial tissues and gradually improved subjective symptoms and clinical findings in patients with adenomyosis and myoma.

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Abstract

We investigated the effect of local injections of danazol suspension (DZS) into the uterine cervix. In the cervix, danazol (DZ) reached high concentrations 1 and 4-6 h after injection; then it decreased. In the endometrium, the DZ level reached a peak 1 h after injection, and then declined. On the other hand, the DZ concentration tended to increase with time after injection in ovarian tissue and it remained at a relatively constant level for more than 2 days. During treatment with DZS, various subjective symptoms and clinical findings gradually improved from the 4th week after the start of injection onward. Moreover, an improvement of subjective symptoms was observed in all the patients by the 24th week.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Cervix Uteri Danazol Endometriosis Leiomyoma Uterine Neoplasms Adult Adult Alanine Transaminase Alanine Transaminase Alanine Transaminase Aspartate Aminotransferases Aspartate Aminotransferases Aspartate Aminotransferases Cervix Uteri Cervix Uteri Danazol Danazol Danazol Danazol Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (19)

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