Psychometric assessment of the health-related productivity questionnaire (HRPQ) among women with endometriosis

Robin Pokrzywinski, Robin M Pokrzywinski, Ahmed M Soliman, Jun Chen, Michael C Snabes, Sanjay K Agarwal, Charles Coddington, Charles C. Coddington, Karin S Coyne
Expert review of pharmacoeconomics & outcomes research · 2019 · vol. 20(5) , pp. 531–539 · doi:10.1080/14737167.2019.1662301 · PMID:31530044 · W2974114143
article OA: hybrid CC0 ⤵ 6 in-corpus citations
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This study validated the Health-Related Productivity Questionnaire (HRPQ) and found it to be a responsive tool for assessing work and household productivity in women with endometriosis.

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Abstract

Objective: Endometriosis impacts health-related quality of life. The objective was to assess the validity and responsiveness of the Health-Related Productivity Questionnaire, version 2 (HRPQ).Methods: Outcome measures (Endometriosis Health Profile-30; pain scales; and global assessment) from Elaris Endometriosis I and II clinical trials (EM-I, EM-II) were used. Validity testing using Cohen’s conventions was assessed. Known-groups validity was evaluated using generalized linear models comparing clinical responders, assessment of change, and the endometriosis impact. The effect size (ES) and standard error of means were calculated to evaluate responsiveness.Results: 871 and 815 women participated in the EM-I and EM-II trials. The total hours of lost work among employed women were 16.5 (±11.4) hours per week for EM-I and 15.2 (±11.3) for EM-II. The total hours of lost work among the household group were 8.3 (±8.7) hours for EM-I and 8.4 (±9.0) hours for EM-II. HRPQ discriminated between all known group assessments tested. Correlations for the HRPQ compared to other measures were small to moderate. Moderate to large ES was observed and the ability of the HRPQ to detect change was strong using patient-reported impressions.Conclusion: The HRPQ is a valid and responsive tool for evaluating patient-reported productivity at work and at home among women with endometriosis.

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Outcome instruments

EHP-30

Condition tags

endometriosis

MeSH descriptors

Efficiency Endometriosis Quality of Life Surveys and Questionnaires Absenteeism Adult Endometriosis Endometriosis Female Humans Pain Pain Pain Measurement Psychometrics Young Adult

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