Role of microRNA in the occurrence and development of endometriosis
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Abstract
微小RNA(microRNA,miRNA)是由22个核苷酸组成的非编码单链小分子RNA,通过与靶mRNA互补配对而在转录后水平上对基因的表达进行负调控,导致mRNA的降解或翻译抑制.1993年,miRNA首次在秀丽隐杆线虫中被发现[1],现已证实,miRNA广泛存在于真核生物细胞内,是最大的基因家族之一,其参与调节生命过程中一系列重要进程,包括细胞发育、分化、增殖和凋亡[2].最新的研究表明,miRNA作为表观遗传修饰的手段和结果之一,可能在子宫内膜异位症(内异症)的发生、发展和预后中发挥重要作用,从而为内异症的诊断和治疗提供新的突破口[3].本文就其相关内容及研究进展综述如下。
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Cited by (3)
- MiR-10b Directly Targets ZEB1 and PIK3CA to Curb Adenomyotic Epithelial Cell Invasiveness via Upregulation of E-Cadherin and Inhibition of Akt Phosphorylation 2015
- MiR-30c-5p Directly Targets MAPK1 to Regulate the Proliferation, Migration and Invasion of Adenomyotic Epithelial Cells in Adenomyosis 2021
- <scp>LncRNA MIR22HG</scp> is downregulated in adenomyosis and upregulates <scp>miR</scp>‐2861 through demethylation to inhibit endometrial cell proliferation 2021
Cited by (3)
- MiR-30c-5p Directly Targets MAPK1 to Regulate the Proliferation, Migration and Invasion of Adenomyotic Epithelial Cells in Adenomyosis 2021
- <scp>LncRNA MIR22HG</scp> is downregulated in adenomyosis and upregulates <scp>miR</scp>‐2861 through demethylation to inhibit endometrial cell proliferation 2021
- MiR-10b Directly Targets ZEB1 and PIK3CA to Curb Adenomyotic Epithelial Cell Invasiveness via Upregulation of E-Cadherin and Inhibition of Akt Phosphorylation 2015
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
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