A prospective, randomized trial comparing two different intrauterine insemination regimens in controlled ovarian hyperstimulation cycles

Kaylen M. Silverberg, K M Silverberg, Julia V. Johnson, J V Johnson, David L. Olive, D L Olive, William N. Burns, W N Burns, Robert S. Schenken, R S Schenken
Fertility and sterility · 1992 · vol. 57(2) , pp. 357–361 · doi:10.1016/s0015-0282(16)54845-6 · PMID:1735488 · W2410033156
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This randomized trial compared two intrauterine insemination regimens during controlled ovarian hyperstimulation and reported their comparative efficacy.

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Abstract

OBJECTIVE: To compare a single periovulatory intrauterine insemination (IUI) with a regimen employing two IUIs, one before ovulation and one after ovulation, in patients undergoing controlled ovarian hyperstimulation with human menopausal gonadotropins (hMG) combined with human chorionic gonadotropin (hCG). DESIGN: A randomized, prospective trial. PARTICIPANTS: Thirty-one consecutive patients undergoing 49 cycles of controlled ovarian hyperstimulation/IUI were studied in a tertiary care setting. MAIN OUTCOME MEASURES: Ovulation was determined sonographically. The establishment of a clinical pregnancy was defined by either ultrasonographic verification of cardiac activity within an intrauterine fetus, or histologic confirmation of trophoblast in a surgical specimen. RESULTS: Clinical pregnancies developed in 2 of 23 cycles in the single insemination group, compared with 12 of the 23 cycles in the double insemination group. Cycle fecundity was significantly higher for group II (0.522) than for group I (0.087) patients (P = 0.003). CONCLUSION: In hMG/hCG cycles, two IUIs timed as described above are superior to one periovulatory insemination.

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MeSH descriptors

Insemination, Artificial Menotropins Ovary Cryopreservation Female Humans Insemination, Artificial Male Menotropins Ovary Ovulation Pregnancy Prospective Studies Spermatozoa Sperm Count Sperm Motility

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