CURRENT STATE OF THE PROBLEM OF MENSTRUAL CYCLE DISORDERS IN WOMEN OF REPRODUCTIVE AGE WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA (LITERATURE REVIEW)

Igor Yu. Rakytianskyi
In: Bulletin of Problems Biology and Medicine · 2024 · vol. 1(1) , pp. 69 · doi:10.29254/2077-4214-2024-1-172-69-75 · W4393170122
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This literature review explores the current state of menstrual cycle disorders in women with undifferentiated connective tissue dysplasia, aiming to improve diagnosis and treatment for enhanced reproductive health.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This literature review analyzes the current state of menstrual cycle disorders in women of reproductive age with undifferentiated connective tissue dysplasia (UCTD), drawing on studies identified via PubMed, Medline, and the Cochrane Library over the prior 10 years. It synthesizes evidence that menstrual dysfunction in this population—most commonly dysmenorrhea and abnormal uterine bleeding—is linked to proposed interactions between sex hormones and immune dysregulation, including autoimmune changes and inflammation, while noting that it is difficult to determine whether hormonal abnormalities result from disease versus treatment and that hormone measurements before disease are often unavailable. The review further summarizes available findings that UCTD is associated with worse pregnancy outcomes, including higher rates of miscarriage and pregnancy complications, and that women with connective tissue disorders may exhibit phenotypic signs in the maternal context. The paper states limitations including UCTD’s clinical heterogeneity, lack of uniform terminology and diagnostic criteria, and incomplete standardization of diagnostic methods. Relevance to endometriosis: the review explicitly mentions that menstrual cycle disorders can present alongside uterine fibroids, endometriosis, and adenomyosis, though its main focus is UCTD-related menstrual dysfunction.

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Abstract

improve the process of diagnosis and treatment of the specified category of patients, which will contribute to the improvement of the reproductive health of the future generation.

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