Disease and its Effects on Fertility

In: Natural Human Fertility · 1988 · pp. 153–160 · doi:10.1007/978-1-349-09961-0_11 · W2496774527
book-chapter OA: closed CC0
Full text JSON View on OpenAlex View at publisher
AI-generated summary by gemini-2.5-flash-lite, 2026-06-08

Current methods of assessing disease effects on fertility are invalid due to voluntary infertility, requiring studies of infertile couples with controls or defined populations.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text

This chapter examines how disease can affect fertility, arguing that traditional community-level epidemiologic approaches no longer work because infertility may be voluntary (via contraceptive mechanisms), so precontraceptive methods misclassify fertility outcomes. The author proposes studying couples seeking treatment for infertility and documenting the associated diseases potentially involved, while emphasizing a need for a defined population or an appropriate control group. The chapter notes that some data exist from smaller population studies such as Hull et al. (1985), but overall numbers remain limited due to heterogeneous combinations of male and female conditions, and there are no adequate datasets describing disease-fertility relationships in generally fertile groups. Relevance to endometriosis: endometriosis is not a specific focus of the chapter’s main argument, but the provided references include studies directly about endometriosis, such as a randomized trial of gestrinone and work on endocrine and follicle growth abnormalities in infertile women with minor endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Fertility has been described in demographic and epidemiological terms. However, although one can describe diseases. in the same community as one documents the pattern of fertility, it is not at present possible to describe the effect of these diseases of fertility. This is because today infertility may be voluntary or involuntary, voluntary infertility being effected through contraceptive mechanisms. There is no study relating disease and fertility that takes into account the impact of voluntary infertility. Methods of population assessment that were feasible in the precontraceptive era are no longer valid. To describe the relationship, one must therefore take couples seeking treatment for their infertility and describe the associated diseases that may be thought to be causative. For such studies to be valid, one must either have a defined population or have a control group. Data on the former have been presented by Hull et al. (1985) but the numbers are still relatively small because of the diversity of conditions and the combinations of problems in both male and female partners. There are no data available that adequately describe the relationships of the pattern in normally fertile groups.
Full text 4,035 characters · extracted from oa-doi-fallback · 3 sections · click to expand

Abstract

Fertility has been described in demographic and epidemiological terms. However, although one can describe diseases. in the same community as one documents the pattern of fertility, it is not at present possible to describe the effect of these diseases of fertility. This is because today infertility may be voluntary or involuntary, voluntary infertility being effected through contraceptive mechanisms. There is no study relating disease and fertility that takes into account the impact of voluntary infertility. Methods of population assessment that were feasible in the precontraceptive era are no longer valid. To describe the relationship, one must therefore take couples seeking treatment for their infertility and describe the associated diseases that may be thought to be causative. For such studies to be valid, one must either have a defined population or have a control group. Data on the former have been presented by Hull et al. (1985) but the numbers are still relatively small because of the diversity of conditions and the combinations of problems in both male and female partners. There are no data available that adequately describe the relationships of the pattern in normally fertile groups. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

American Fertility Society. (1985) ‘Revised American Fertility Society Classification of Endometriosis’, Fertility and Steri., vol. 43, pp. 351–2. Belsey, M. (1976) ‘The Epidemiology of Infertility: a Review with Particular Reference to Sub-Saharan Africa’, Bulletin of the World Health Organiza., vol. 54, pp. 319–41. Brosens, I.A., Koninckx, P.R. and Corvelyn, P.A. (1978) ‘A Study of Plasma Progesterone 17 ß Oestradiol Prolactin and LH Levels of the Luteal Phase and Appearance of the Ovaries in Patients with Endometriosis’, British Journal of Obstetrics and Gynaeco., vol. 85, pp. 246–50. Cates, W., Farley, T.M. and Rowe, P.J. (1985) ‘Worldwide Patterns of Infertility: Is Africa Different?’ La., vol. ii, pp. 596–8. Hull, M.G.R., Glazener, C.M.A., Kelly, N.J., Conway, D.I., Foster, P.A., Hinton, R.A., Coulson, C., Lambert, P.A., Watt, E. and Desai, K.M. (1985) ‘Population Study of Courses, Treatment and Outcome of Infertility’, British Medical Jou., vol. 291, pp. 1693–7. Kratochwil, A., Erban, G. and Friedrich, F. (1972) ‘Ultrasonic Tomography of the Ovaries’, Annals Chirorgiae Gynaecolo., vol. 61, pp. 211–4. Rubin, G.L., Ory, H.W. and Layde, P.M. (1982) ‘Oral contraceptives and pelvic inflammatory disease’, American Journal of Obstetrics and Gyneco., vol. 144, pp. 630–5. Thomas, E.J. and Cooke, I.D. (1986) ‘A Randomised Double Blind, Placebo Controlled Trial of Gestrinone in the Treatment of Asymptomatic Endometriosis’, British Medical Jour. (In press). Thomas, E.J., Lenton, E.A. and Cooke, I.D. (1986) ‘Follicle Growth Patterns and Endocrinological Abnormalities in Infertile Women with Minor Degrees of Endometriosis’, British Journal of Obstetrics and Gynaeco., vol. 93, pp. 852–8. Westrom, L. (1980) ‘Incidence Prevalence and Trends of Acute Pelvic Inflammatory Disease and Its Consequences in Industrialised Countries’, American Journal of Obstetrics and Gyneco., vol. 138, pp. 880–92. Editor information Editors and Affiliations Copyright information © 1988 The Eugenics Society About this chapter Cite this chapter Cooke, I.D. (1988). Disease and its Effects on Fertility. In: Diggory, P., Potts, M., Teper, S. (eds) Natural Human Fertility. Studies in Biology, Economy and Society. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-09961-0_11 Download citation DOI: https://doi.org/10.1007/978-1-349-09961-0_11 Publisher Name: Palgrave Macmillan, London Print ISBN: 978-1-349-09963-4 Online ISBN: 978-1-349-09961-0 eBook Packages: Palgrave Social & Cultural Studies CollectionSocial Sciences (R0)

Keywords

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

infertility

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

References (11)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-08-24T06:27:14.670421+00:00
License: CC0 · commercial use OK