An Update on the Innovative Part of NLRP3 Inflammasome Regarding Newer Strategies for Treatment of Reproductive Conditions Possessing Greater Risk: A Systematic Review

Kaur KK
In: Open Access Journal of Gynecology · 2022 · vol. 7(3) , pp. 1–13 · doi:10.23880/oajg-16000237 · W4367278981
review OA: diamond CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This systematic review details the mechanism of the NLRP3 inflammasome and its role in reproductive conditions including RSA, PCOS, GDM, PE, preterm birth, and ovarian aging, and explores novel non-hormonal therapies for endometriosis.

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Abstract

Earlier we reviewed the role of NOD –like receptor protein (NLRP3) inflammasome in different patients presenting with various metabolic disorders is type 2 Diabetes mellitus obesity, Metabolic Syndrome (MetS), non-alcoholic fatty liver disease subjects NAFLD, non-alcoholic steatohepatitis (NASH). Thus Here we conducted a systematic review utilizing search engine PubMed, google scholar ;web of science; embase; Cochrane review library utilizing the MeSH terms like NLRP3 inflammasome; mode of action; recurrent spontaneous abortions (RSA); Gestational Diabetes mellitus(GDM); endometriosis; preterm birth; Polycystic ovary syndrome (PCOS); preeclampsia ;leaky gut;IL-1β;IL-18;caspase 1. We found a total of 150 articles out of which we selected 100 articles for this review. No meta-analysis was done. Here we have detailed the mechanism of action of NLRP3 inflammasome, their part in RSA, PCOS, GDM, PE, preterm birth, ovarian aging and newer non hormonal therapy for endometriosis& other practical applications

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endometriosis

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