Extra-ordinary High CA-125 and CA19-9 Serum Levels in an Ovarian Endometrioma: Case Report

Marzieh Agha Hosseini, Ashraf Aleyasin, Sepideh Khodaverdi, Atossa Mahdavi, Zahra Najmi
In: Journal of Family and Reproductive Health, Vol 3, Iss 2 (2009) · 2009 · W2298820212
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This case report describes an unruptured ovarian endometrioma associated with exceptionally high serum CA-125 and CA19-9 levels, highlighting the need to consider benign conditions in elevated tumor marker diagnoses.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper is a case report describing a 29-year-old woman with a diffuse, unruptured ovarian endometrioma who had exceptionally high serum CA-125 and CA19-9 levels, values that are typically more associated with advanced ovarian carcinoma. The authors note that while CA-125 is often elevated in moderate to severe endometriosis, unruptured endometriosis generally has CA-125 levels rarely exceeding 1000 U/mL. The primary contribution is documenting this unusual pattern of tumor-marker elevation in a benign gynecologic condition and emphasizing the need to consider endometrioma as a differential diagnosis for exaggerated CA-125. This paper is centrally about endometriosis — it reports an ovarian endometrioma with extraordinarily high CA-125 and CA19-9 levels.

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Abstract

Endometriosis is an estrogen dependent disease. Levels of Cancer antigen-125 are significantly higher in women with moderate to severe endometriosis. However, patients with unruptured endometriosis rarely have serum CA-125 levels more than 1000 U/mL. This case report presents a diffuse, unruptured ovarian endometrioma in a 29- year-old woman, leading to an extraordinary high serum CA-125 and CA19-9 levels; usually typical of advanced ovarian carcinoma. Our experience emphasizes on benign gynecologic conditions such as endometrioma, which should be taken into account as a possible differential diagnosis in women with exaggerated elevation of the serum CA-125 level.
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Journal of Family and Reproductive Health (Jun 2009) Extra-ordinary High CA-125 and CA19-9 Serum Levels in an Ovarian Endometrioma: Case Report Abstract Endometriosis is an estrogen dependent disease. Levels of Cancer antigen-125 are significantly higher in women with moderate to severe endometriosis. However, patients with unruptured endometriosis rarely have serum CA-125 levels more than 1000 U/mL. This case report presents a diffuse, unruptured ovarian endometrioma in a 29- year-old woman, leading to an extraordinary high serum CA-125 and CA19-9 levels; usually typical of advanced ovarian carcinoma. Our experience emphasizes on benign gynecologic conditions such as endometrioma, which should be taken into account as a possible differential diagnosis in women with exaggerated elevation of the serum CA-125 level.

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endometriosisendometrioma

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