Danazol inhibition of steroidogenesis in the human corpus luteum

Obstetrics & Gynecology · 1981 · vol. 57(6) , pp. 722–4 · PMID:6940056 · W2333212790
Lab / animal OA: closed CC0 ⤵ 13 in-corpus citations
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Danazol directly inhibited multiple human corpus luteum steroidogenic enzymes including 3 beta-hydroxysteroid dehydrogenase, 17,20-lyase, 17 alpha-hydroxylase, and 17 beta-hydroxysteroid dehydrogenase, but not aromatase.

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Abstract

In human corpus luteum (CL) microsomes, danazol inhibited 3 beta-hydroxysteroid dehydrogenase, 17,20-lyase, 17 alpha-hydroxylase, and 17 beta-hydroxysteroid dehydrogenase enzymes. Danazol did not inhibit aromatase. The observation that danazol can directly inhibit multiple enzymes of CL steroidogenesis may provide a molecular basis for explaining previous reports that danazol inhibits CL steroidogenesis in the monkey in vivo.

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MeSH descriptors

Corpus Luteum Danazol Hydroxysteroid Dehydrogenases Pregnadienes Adult Aromatase Aromatase Corpus Luteum Corpus Luteum Corpus Luteum Danazol Female Humans Hydroxysteroid Dehydrogenases Hydroxysteroid Dehydrogenases Lyases Lyases Mixed Function Oxygenases Mixed Function Oxygenases Pregnadienes

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