Building a stem cell-based primate uterus

Sophie Bergmann, Magdalena Schindler, Clara Munger, Christopher A. Penfold, Thorsten Boroviak
Communications biology · 2021 · vol. 4(1) , pp. 749 · doi:10.1038/s42003-021-02233-8 · PMID:34140619 · PMC8211708 · W3169579436
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Abstract

The uterus is the organ for embryo implantation and fetal development. Most current models of the uterus are centred around capturing its function during later stages of pregnancy to increase the survival in pre-term births. However, in vitro models focusing on the uterine tissue itself would allow modelling of pathologies including endometriosis and uterine cancers, and open new avenues to investigate embryo implantation and human development. Motivated by these key questions, we discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organising cultures, or by controlled assembly through microfluidic and print-based technologies.

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Condition tags

endometriosis

MeSH descriptors

Stem Cells Tissue Engineering Uterus Uterus Animals Embryo Implantation Embryo Implantation Female Fetal Development Fetal Development Humans Models, Biological Placenta Placenta Pregnancy Primates Stem Cells Tissue Engineering Tissue Scaffolds Uterus

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