Endometrial Organoids: A New Model for the Research of Endometrial-Related Diseases†

Zhiyue Gu, Shuangzheng Jia, Song Liu, Jinhua Leng
In: Biology of Reproduction · 2020 · vol. 103(5) , pp. 918–926 · doi:10.1093/biolre/ioaa124 · PMID:32697306 · W3044207631
review OA: bronze CC0 ⤵ 8 in-corpus citations
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Abstract

An ideal research model plays a vital role in studying the pathogenesis of a disease. At present, the most widely used endometrial disease models are cell lines and animal models. As a novel studying model, organoids have already been applied for the study of various diseases, such as disorders related to the liver, small intestine, colon, and pancreas, and have been extended to the endometrium. After a long period of exploration by predecessors, endometrial organoids (EOs) technology has gradually matured and maintained genetic and phenotypic stability after long-term expansion. Compared with cell lines and animal models, EOs have high stability and patient specificity. These not only effectively and veritably reflects the pathophysiology of a disease, but also can be used in preclinical drug screening, combined with patient derived xenografts (PDXs). Indeed, there are still many limitations for EOs. For example, the co-culture system of EOs with stromal cells, immune cell, or vascular cells is not mature, and endometrial cancer organoids have a lower success rate, which should be improved in the future. The investigators predict that EOs will play a significant role in the study of endometrium-related diseases.

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