Evidence-based management of Mastalgia: a meta-analysis of randomised trials

Anurag Srivastava, A Srivastava, Robert E. Mansel, R E Mansel, NandKishore Arvind, N Arvind, Kameshwar Prasad, K Prasad, Anita Dhar, A Dhar, A Chabra, Aroona Chabra
Breast (Edinburgh, Scotland) · 2007 · vol. 16(5) , pp. 503–512 · doi:10.1016/j.breast.2007.03.003 · PMID:17509880 · W2063316507
Systematic review / meta-analysis OA: closed CC0 ⤵ 9 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This meta-analysis of randomized trials provides evidence-based recommendations for managing mastalgia, aiming to guide clinical practice and improve patient outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Several agents have been utilised for therapy of mastalgia based on data from small trials. No meta-analysis of trials on mastalgia exists. We have conducted a meta-analysis on trials on mastalgia published in the English language. Study was restricted to randomised controlled trials comparing Bromocriptine, Danazol, Evening primrose oil (EPO) and Tamoxifen with placebo. The analysis was carried out on the REVMAN statistical package. Weighted mean difference in the pain score in favour of Bromocriptine was -16.31(95% CI -26.35 to -6.27). Danazol produced a significant benefit with a mean pain score difference -20.23(95% CI -28.12 to -12.34). EPO did not offer any advantage over placebo in pain relief, mean pain score difference being -2.78 (95% CI -7.97 to 2.40). Tamoxifen achieved a relative risk (RR) of pain relief of 1.92 (95% CI 1.42-2.58). Tamoxifen is associated with least side effects and should be the drug of first choice.

My notes (saved in your browser only)

MeSH descriptors

Breast Diseases Estrogen Antagonists Pain Selective Estrogen Receptor Modulators Breast Diseases Bromocriptine Bromocriptine Danazol Danazol Estrogen Antagonists Female Humans Pain Pain Measurement Phytotherapy Plant Oils Plant Oils Primula Randomized Controlled Trials as Topic Selective Estrogen Receptor Modulators

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (23)

Cited by (7)

Source provenance

openalex
last seen: 2026-05-11T06:39:27.580236+00:00
pubmed
last seen: 2026-10-08T21:04:24.806248+00:00
unpaywall
last seen: 2026-10-18T06:28:46.490043+00:00
License: CC0 · commercial use OK