Progestin Selectivity in Clinical Applications

Hisham Arab
In: Progesterone - Basic Concepts And Emerging New Applications · 2024 · doi:10.5772/intechopen.1004820 · W4400243213
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This review details the specific biological, pharmacological, and clinical characteristics of synthetic progestins, especially dydrogesterone, in various obstetric and gynecologic applications like miscarriage, luteal phase support, and endometriosis.

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Abstract

This chapter presents a thorough examination of synthetic progestins in obstetric and gynecologic practice, highlighting their specific use in several clinical scenarios, including miscarriage, luteal phase support, menstrual problems, and endometriosis. Drawing from existing literature, the chapter explores the specific biological, pharmacological, and clinical characteristics of progestins -especially dydrogesterone -emphasizing their subtle functions in different reproductive health conditions. The study primarily revolves around dydrogesterone, with a thorough investigation that includes data extracted from the literature on its molecular structure, in vitro and in vivo findings, clinical data obtained from randomized clinical trials, and systematic reviews. This chapter intends to provide the reader with a detailed understanding of the distinct clinical applications and differential selectivity of synthetic progestins, with a particular focus on the unique features of dydrogesterone. The goal is to equip the reader with a nuanced comprehension of these drugs. This resource is beneficial for healthcare practitioners, researchers, and academicians who want a more detailed understanding of the complex relationship between synthetic progestins and reproductive health in different clinical situations.

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Condition tags

endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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