DNA fragmentation, DNA repair and apoptosis induced in primary rat hepatocytes by dienogest, dydrogesterone and 1,4,6-androstatriene-17β-ol-3-one acetate

Francesca Mattioli, Claudia Garbero, Marzia Gosmar, Valeria Manfredi, Roberto Carrozzino, Antonietta Martelli, Giovanni Brambilla
In: Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2004 · vol. 564(1) , pp. 21–29 · doi:10.1016/j.mrgentox.2004.07.006 · PMID:15474407 · W1964648409
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated dienogest, dydrogesterone, and 1,4,6-androstatriene-17β-ol-3-one acetate's effects on rat hepatocytes, finding they induce DNA fragmentation, DNA repair, and apoptosis.

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