Efficacy of micronised vaginal progesterone versus oral dydrogestrone in the treatment of irregular dysfunctional uterine bleeding: A pilot randomised controlled trial

Savaş Karakuş, Gürkan Kıran, Harun Çıralık
In: Australian and New Zealand Journal of Obstetrics and Gynaecology · 2009 · vol. 49(6) , pp. 685–688 · doi:10.1111/j.1479-828x.2009.01093.x · PMID:20070724 · W1977168178
article OA: closed CC0 ⤵ 6 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This pilot randomized controlled trial found no significant difference in menstrual cycle characteristics or endometrial histology between women treated with micronized vaginal progesterone or oral dydrogesterone for irregular dysfunctional uterine bleeding.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: The vaginal route is more effective than the other drug delivery routes for some specific indications. AIM: To compare the efficacy of a vaginal progesterone preparation with that of oral dydrogesterone. METHODS: A total of 69 women with irregular dysfunctional uterine bleeding were randomly assigned into one of two groups: oral dydrogesterone group (n = 35) and vaginal progesterone group (n = 34). At the end of a three-month treatment period, the women were re-evaluated. The endometrial histology findings and menstrual cycle characteristics were used as primary outcome measures. Pearson chi-square and Fisher's exact test were used for data analysis. RESULTS: Findings from 54 eligible women were evaluated. There was no statistically significant difference in both menstrual recordings and endometrial histology results between the groups. CONCLUSIONS: Vaginal micronised progesterone could be an alternative to oral preparations in the treatment of dysfunctional uterine bleeding. This needs to be further evaluated in adequately controlled randomised trials against other effective treatments.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (35)

Cited by (6)

Source provenance

openalex
last seen: 2026-05-11T06:00:05.006021+00:00
License: CC0 · commercial use OK