A case of high-grade endometrial stromal sarcoma arising from endometriosis in the cul-de-sac

Kusaka M, Masumi Kusaka, M Kusaka, Mikuni M, M Mikuni, Nishiya M, Masashi Nishiya, M Nishiya
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2006 · vol. 16(2) , pp. 895–899 · doi:10.1111/j.1525-1438.2006.00236.x · PMID:16681780 · W1997309699
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This case report details a high-grade endometrial stromal sarcoma that arose from endometriosis in the cul-de-sac of a 37-year-old woman, highlighting ESS as a differential diagnosis for malignant endometriosis transformation.

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Abstract

This report describes a rare case of high-grade endometrial stromal sarcoma (ESS) arising from pathologically confirmed endometriosis in the cul-de-sac. A 37-year-old woman presented with irregular menstruation, pelvic pain, and diarrhea. Magnetic resonance imaging and colon biopsy suggested endometriotic nodule of the cul-de-sac. The tumor size was reduced with hormonal therapy, and the residual tumor was excised, resulting in the pathologic diagnosis of endometriosis. Two years later, a soft mass reappeared with rapid growth. Tumor extraction was performed, and the histopathologic diagnosis was high-grade ESS. Neither hormonal therapy nor chemotherapy was effective, and the patient died 6 months postoperatively. ESS should be included in the differential diagnosis of malignant transformation of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Endometrial Neoplasms Endometriosis Sarcoma, Endometrial Stromal Adult Adult Cell Transformation, Neoplastic Cell Transformation, Neoplastic Combined Modality Therapy Combined Modality Therapy Disease Progression Disease Progression Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Fatal Outcome Fatal Outcome

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (12)

Cited by (8)

Source provenance

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