Intracavitary-Electrohysterogram: Novel technique for assessing uterine peristalsis and electrophysiology in non-pregnant women

José Alberola-Rubio; Jose Alberola-Rubio; Alba Diaz-Martinez; Alba Diaz‐Martinez; Juan Miguel Mira-Tomas; Juan Miguel Mira‐Tomas; Pilar Alama Faubel; Sergio Caballero Sanz; Gemma Castillón Cortés; María de Arriba; Maria de Arriba-Garcia; Joaquín Llacer Aparicio; Jorge Aparicio; Javier Garcia-Casado; Javier Garcia‐Casado

doi:10.1016/j.ejogrb.2025.03.042

Intracavitary-Electrohysterogram: Novel technique for assessing uterine peristalsis and electrophysiology in non-pregnant women

José Alberola-Rubio, Jose Alberola-Rubio, Alba Diaz-Martinez, Alba Diaz‐Martinez, Juan Miguel Mira-Tomas, Juan Miguel Mira‐Tomas, Pilar Alama Faubel, Sergio Caballero Sanz, Gemma Castillón Cortés, María de Arriba, Maria de Arriba-Garcia, Joaquín Llacer Aparicio, Jorge Aparicio, Javier Garcia-Casado, Javier Garcia‐Casado

European journal of obstetrics, gynecology, and reproductive biology · 2025 · vol. 309 , pp. 131–136 · doi:10.1016/j.ejogrb.2025.03.042 · PMID:40133009 · W4408540293

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Researchers developed a novel intracavitary-electrohysterogram technique to assess uterine peristalsis and electrophysiology in non-pregnant women.

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Abstract

BACKGROUND: Uterine peristalsis plays a crucial role in fertility and is affected by various disorders and pathologies. Its knowledge and assessment are very limited with current monitoring techniques. OBJECTIVE: The aim is to objectively and quantitatively characterize menstrual uterine peristalsis using a new technique, intracavitary electrohysterogram (IC-EHG). METHODS: This pilot multicenter study recorded IC-EHG by means of a multipolar catheter in a prospective cohort of 15 healthy women with proven fertility across three menstrual phases: mid-follicular (MF), early luteal (EL), and late luteal (LL). To describe and compare uterine peristaltic patterns, characteristics such as contraction frequency, duration, amplitude, and energy were calculated. RESULTS: The IC-EHG recordings revealed statistically significant patterns throughout the menstrual phases. Uterine contractions were less frequent (3.2 CT/min), more intense and of longer duration during the MF phase. As the menstrual cycle progressed to the EL and LL phases, the frequency of contractions increased (3.7 and 3.5 CT/min, respectively) while both amplitude and duration declined. CONCLUSIONS: The intracavitary electrohysterogram (IC-EHG) effectively quantifies menstrual cycle-dependent uterine peristalsis and electrophysiological patterns, providing initial reference values for uterine bioelectrical activity in fertile women. This novel technique represents a significant advance in assessing uterine physiology, with potential use as a diagnostic tool for real-time uterine health monitoring, supporting gynecological treatment and planning, and aiding in assisted reproductive technologies through objective metrics of uterine activity.

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MeSH descriptors

Electromyography Electromyography Menstrual Cycle Menstrual Cycle Peristalsis Peristalsis Uterine Contraction Uterine Contraction Uterus Uterus Adult Female Humans Pilot Projects Prospective Studies Young Adult

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[2] Endometrial wave-like activity in the non-pregnant uterus via openalex

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