Extrauterine müllerian adenosarcoma associated with endometriosis and rectal villotubular adenoma: report of a case and review of the literature

H-Y Chang, Chang HY, Hsiu-Neng Chang, C C Changchien, C-C Changchien, Changchien CC, H.-H. Chen, Chen HH, Hao Lin, H Lin, Huang CC, C-C Huang
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2005 · vol. 15(2) , pp. 361–365 · doi:10.1111/j.1525-1438.2005.15230.x · PMID:15823126 · W2051746655
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This case report describes an extrauterine mullerian adenosarcoma found in association with endometriosis and a rectal villotubular adenoma, along with a review of existing literature on these rare co-occurrences.

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Abstract

Extrauterine mullerian adenosarcoma is rare and is thought to arise from endometriotic deposits or pluripotent mesothelial and mesenchymal cells of the pelvic cavity. Concomitant colon-rectal neoplasm was reported but the relationship between extrauterine adenosarcoma and colon tumor was not studied. We describe an extrauterine adenosarcoma with a concomitant rectal tubulovillous adenoma. The patient had a long-term history of endometriosis and unopposed estrogen therapy. Immunohistochemical study was performed to investigate the origin and nature of the adenosarcoma. Immunostaining provided the evidence to distinguish between rectal tumor and adenosarcoma. Extrauterine adenosarcoma may arise from endometriosis, and hormone replacement therapy may have some role in the malignant transformation process. Adenosarcoma should be considered in the differential diagnosis of a new pelvic tumor in a patient with a history of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Adenoma Adenosarcoma Adenosarcoma Endometriosis Neoplasms, Multiple Primary Rectal Neoplasms Adenoma Adenoma Adenosarcoma Adenosarcoma Adult Adult Cell Transformation, Neoplastic Cell Transformation, Neoplastic Endometriosis Endometriosis Female Female Hormone Replacement Therapy Hormone Replacement Therapy

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (17)

Cited by (10)

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