DIETARY INTERVENTIONS AND THEIR EFFECTIVENESS IN THE TREATMENT OF ENDOMETRIOSIS - NARRATIVE REVIEW

In: International Journal of Innovative Technologies in Social Science · 2026 · doi:10.31435/ijitss.1(49).2026.4844 · W7131209396
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This review analyzed 19 studies on dietary interventions for endometriosis, finding that while the Mediterranean diet shows promise for symptom management, more restrictive diets like Low-FODMAP and gluten-free diets are effective but harder to adhere to.

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This narrative review synthesized 19 original studies on dietary interventions and their effectiveness for endometriosis, aiming to summarize current evidence on reducing symptoms and risk, including Mediterranean, low-FODMAP, and gluten-free approaches plus other diet components. Most included studies reported positive effects on endometriosis-related symptoms, with the Mediterranean diet described as a plausible adjunct therapy with fewer adherence challenges, whereas more restrictive regimens like low-FODMAP and gluten-free diets were also reported to alleviate symptoms but were harder to adhere to. The authors emphasize that more well-designed randomized controlled trials are needed to clarify short- and long-term effectiveness and safety. This paper is centrally about endometriosis — it is a narrative review focused on dietary interventions and their reported effectiveness for symptom management and risk reduction.

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Abstract

Endometriosis is a chronic and complex systematic condition that impacts approximately 10% of women of reproductive age worldwide. Available literature has shown that selected diets have positive effects on the development and course of endometriosis. This review aimed to present current data on various dietary interventions and their effectiveness in reducing endometriosis symptoms and risk. The 19 included original studies were analyzed and included in the review. Most of the studies reported a positive effect on endometriosis-related symptoms. The Mediterranean diet was reported as a plausible adjunct therapy for symptom management without difficulty in adherence. More restrictive diet regimens, such as the Low-FODMAP diet and gluten-free diet, were reported to alleviate endometriosis-related symptoms, however adherence proved to be more difficult. Further well-designed randomized controlled trials are crucial to determine the short-term and long-term effectiveness and safety of different dietary interventions.
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DIETARY INTERVENTIONS AND THEIR EFFECTIVENESS IN THE TREATMENT OF ENDOMETRIOSIS - NARRATIVE REVIEW DOI: https://doi.org/10.31435/ijitss.1(49).2026.4844Keywords: Endometriosis, Diet, TreatmentAbstract Endometriosis is a chronic and complex systematic condition that impacts approximately 10% of women of reproductive age worldwide. Available literature has shown that selected diets have positive effects on the development and course of endometriosis. This review aimed to present current data on various dietary interventions and their effectiveness in reducing endometriosis symptoms and risk. The 19 included original studies were analyzed and included in the review. Most of the studies reported a positive effect on endometriosis-related symptoms. The Mediterranean diet was reported as a plausible adjunct therapy for symptom management without difficulty in adherence. More restrictive diet regimens, such as the Low-FODMAP diet and gluten-free diet, were reported to alleviate endometriosis-related symptoms, however adherence proved to be more difficult. Further well-designed randomized controlled trials are crucial to determine the short-term and long-term effectiveness and safety of different dietary interventions. References Varney, J.E., So, D., Gibson, P.R., Rhys-Jones, D., Lee, Y.S.J., Fisher, J., Moore, J.S., Ratner, R,. Morrison ,M., Burgell, R.E. and Muir, J.G. Clinical Trial: Effect of a 28-Day Low FODMAP Diet on Gastrointestinal Symptoms Associated With Endometriosis (EndoFOD)—A Randomised, Controlled Crossover Feeding Study; Alimentary Pharmacology & Therapeutics, 2025; 61:1889–1903 10.1111/apt.70161 Van Haaps, A.P., Wijbers, J.V., Schreurs, A.M.F., Vlek, S., Tuynman, J., De Bie, B., De Vogel, A.L., Van Wely, M. And Mijatovic, V.: The effect of dietary interventions on pain and quality of life in women diagnosed with endometriosis: a prospective study with control group; Human Reproduction, 2023, 38(12), 2433–2446 10.1093/humrep/dead214 Krabbenborg, I., De Roos, N., Van der Grinten, P. and Nap, A.: Diet quality and perceived effects of dietary changes in Dutch endometriosis patients: an observational study; Elsevier Ltd on behalf of Reproductive Healthcare Ltd 2021 10.1016/j.rbmo.2021.07.011 1472-6483 Keukens, A., Veth, V.B., Van de Kar, M.M.A., Bongers, M.Y., Coppus, S.F.P.J. and Maas, J.W.M.: Effects of a low-FODMAP diet on patients with endometriosis, a prospective cohort study BMC Women’s Health 2025 25:174 10.1186/s12905-025-03715-1 Cirillo, M., Argento, F.R., Becatti, M., Fiorillo, C., Coccia, M.E. and Fatini, C.: Mediterranean Diet and Oxidative Stress: A Relationship with Pain Perception in Endometriosis; nt. J.Mol.Sci. 2023, 24,14601. 10.3390/ijms241914601 Noormohammadi, M., Javaheri, F.S.H., Ghasemisedaghat, S., Ghoreishy, S.M., Eslamian, G., Nouri, M., Kazemi, S.N., Nematifard, E., Rashidkhani, B. and Taheripanah, R.: Mediterranean diet adherence and healthy diet indicator might decrease odds of endometriosis. Scientific Reports, Nature (2025) 15:36750 10.1038/s41598-025-20621-6 Kiani, A.K., Medori, M.C., Bonetti, G., Aquilanti, B., Velluti, V., Matera, G., Iaconelli, A., Stuppia, L., Connely, S.T., Herbst, K.L. and Bertelli, M.: Modern vision of the Mediterranean diet; J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E36–E43. 10.15167/2421-4248/jpmh2022.63.2S3.2745Yannakoulia M. and Scarmeas N.: Diets. N Engl J Med 2024;390:2098-2106 10.1056/NEJMra2211889 Molina, N.M, Jurado-Fasoli, L., Sola-Leyva, A., Sevilla-Lorente, R., Canha-Gouveia, A., Ruiz-Durán, S., Fontes, J., Concepción, M. A., Altmäe, S.: Endometrial whole metabolome profile at the receptive phase: influence of Mediterranean Diet and infertility; Front. Endocrinol. 2023 14:1120988.; 10.3389/fendo.2023.1120988 Abramiuk, M., Mertowska, P., Frankowska, K., Świechowska-Starek, P., Satora, M. Polak, G., Dymanowska-Dyjak, I. and Grywalska, E.: Nutrients 2024 How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis Nutrients 2024, 16(1), 154; 10.3390/nu16010154 Matire, F.G., Constantini, E., d’Abate, C., Capria, G., Piccione, E., Andreoli, A.: Endometriosis and Nutrition: Therapeutic Perspectives; Journal of Clinical Medicine, 2025 J. Clin. 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Liu, Y.C.: Medium-chain triglyceride (MCT) ketogenic therapy; Epilepsia 2008 10.1111/j.1528-1167.2008.01830.x Yannakoulia, M. and Scarmeas, N.: Diets; N Engl J Med 2024;390:2098-2106 10.1056/NEJMra2211889 Noormohammadi, M., Ghoreishy, S.M., Ghasemisedaghat, S., Hasan-Rashedi, M., Saeedirad, Z., Eslamian, G., Kazemi, S.N., Nematifard, E., Rashidkhani, B., Taheripanahe, R. and Nouri, M.: Association between MIND diet its components with endometriosis risk: secondary results from a case- control study; Scientific Reports, Nature 2025 10.1038/s41598-025-04593-1 Guo, J.J., Li, R.X., Shang, W.L., Zheng, Y.F., Zhu, G.Y., Shu, Z.C., Liu, G.C., Ou, H.B, Li, J.Y., Guo, X.G. and Lin, L.H.: Association between dietary selenium intake and endometriosis risk: a cross-sectional analysis; Front. Endocrinol. 16:1486790. 10.3389/fendo.2025.1486790 Zheng, Y.F., Guo, Y.M., Song, C.J., Liu, G.C., Chen, S.Y., Guo, X.G. and Lin, L.H.: A cross-sectional study on the relationship between dietary fiber and endometriosis risk based on NHANES 1999–2006; Scientific Reports (2024) 14:28502, 10.1038/s41598-024-79746-9 Harris, H.R, Chavarro, J.E., Malspeis, S., Willet, W.C. and Missmer, S.A.: Dairy-Food, Calcium, Magnesium, and Vitamin D Intake and Endometriosis: A Prospective Cohort Study; Am J Obstet Gynecol. 2024 October ; 231(4): 443.e1–443.e10. doi:10.1016/j.ajog.2024.04.030. Dougan, M.M., Fest, S., Cushing-Haugen, K., Farland, L.V., Chavarro, J.,Harris, H.R. and Missmer, S.A.: A prospective study of dietary patterns and the incidence of endometriosis diagnosis; Am J Obstet Gynecol. 2024 231(4): 443.e1–443.e10. 10.1016/j.ajog.2024.04.030. Ghoreishy, S.M., Javaheri, F.S.H., Ghasemisedaghat, S., Noormohammadi, M., Eslamian, G., Kazemi, S.N., Rashidkhani, B. and Taheripanah, R.: Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control study; BMC Women's Health 2025 25:249, 10.1186/s12905-025-03805-0 Kumar, K.D., Appleby‐Gunnill, B. and Maslin, K.: Nutritional practices and dietetic provision in the endometriosis population, with a focus on functional gut symptoms. J Hum Nutr Diet. 2023;36:1529–1538. 10.1111/jhn.13158 Vennberg Karlsson, J., Patel, H. and Premberg, A.: Experiences of health after dietary changes in endometriosis: a qualitative interview study. BMJ Open 2020;10:e032321. 10.1136/bmjopen-2019-032321 Downloads Published Issue Section License All articles are published in open-access and licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Hence, authors retain copyright to the content of the articles. 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