Research Progress of FOXP3 and TGF-β1 in Diagnosis and Treatment of Endometriosis

FOXP3、TGF-β1在子宫内膜异位症诊疗中的研究进展 Research Progress of FOXP3 and TGF-β1 in Diagnosis and Treatment of Endometriosis Research Progress of FOXP3 and TGF-β1 in Diagnosis and Treatment of Endometriosis DOI: 10.12677/ACM.2024.142393, PDF, 被引量 作者: 刘佳伟：内蒙古医科大学第一临床医学院，内蒙古 呼和浩特；索 静*：内蒙古医科大学附属医院妇产科，内蒙古 呼和浩特 关键词: 子宫内膜异位症；FOXP3；TGF-β1；免疫抑制；Endometriosis； FOXP3； TGF-β1； Immunosuppression 作者: 刘佳伟：内蒙古医科大学第一临床医学院，内蒙古 呼和浩特；索 静*：内蒙古医科大学附属医院妇产科，内蒙古 呼和浩特 关键词: 子宫内膜异位症；FOXP3；TGF-β1；免疫抑制；Endometriosis； FOXP3； TGF-β1； Immunosuppression 摘要: 子宫内膜异位症严重影响育龄期女性的生活质量，其发病机制至今尚未阐明。调节性T细胞在机体免疫抑制中发挥关键作用，近年来大量研究证明，FOXP3相关免疫抑制可影响肿瘤微环境，在其发生发展中起到关键性作用，肿瘤微环境与内异症局部微环境相似，免疫功能异常在内异症发生发展中至关重要。TGF-β1可在免疫排斥和免疫抑制中发挥作用，参与子宫内膜异位症的发生发展过程。本文主要探究FOXP3、TGF-β1与内异症发病机制的相关性，为其免疫治疗提供新方向。 Abstract: Endometriosis seriously affects the quality of life of women of childbearing age, and its pathogenesis has not been elucidated. Regulatory T cells play a key role in immunosuppression. In recent years, a large number of studies have proved that FOXP3-related immunosuppression can affect the tumor microenvironment and play a key role in its occurrence and development. Tumor microenviron-ment is similar to the local microenvironment of endometriosis, and immune dysfunction plays an important role in the occurrence and development of endometriosis. TGF-β1 may play a role in im-mune rejection and immunosuppression, and participate in the occurrence and development of endometriosis. This article mainly explores the correlation between FOXP3, TGF-β1 and the patho-genesis of endometriosis, and provides a new direction for its immunotherapy. 文章引用：刘佳伟, 索静. FOXP3、TGF-β1在子宫内膜异位症诊疗中的研究进展[J]. 临床医学进展, 2024, 14(2): 2784-2788. https://doi.org/10.12677/ACM.2024.142393 | [1] | Greene, R., Stratton, P., Cleary, S.D., et al. (2009) Diagnostic Experience among 4,334 Women Reporting Surgically Diagnosed Endometriosis. Fertility and Sterility, 91, 32-39. 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