{"paper_id":"14642ba1-a4f3-41b4-b11c-620117ff9612","body_text":"FOXP3、TGF-β1在子宫内膜异位症诊疗中的研究进展\nResearch Progress of FOXP3 and TGF-β1 in Diagnosis and Treatment of Endometriosis\nResearch Progress of FOXP3 and TGF-β1 in Diagnosis and Treatment of Endometriosis\nDOI: 10.12677/ACM.2024.142393,\nPDF,\n被引量\n作者: 刘佳伟：内蒙古医科大学第一临床医学院，内蒙古 呼和浩特；索 静*：内蒙古医科大学附属医院妇产科，内蒙古 呼和浩特\n关键词: 子宫内膜异位症；FOXP3；TGF-β1；免疫抑制；Endometriosis； FOXP3； TGF-β1； Immunosuppression\n作者: 刘佳伟：内蒙古医科大学第一临床医学院，内蒙古 呼和浩特；索 静*：内蒙古医科大学附属医院妇产科，内蒙古 呼和浩特\n关键词: 子宫内膜异位症；FOXP3；TGF-β1；免疫抑制；Endometriosis； FOXP3； TGF-β1； Immunosuppression\n摘要: 子宫内膜异位症严重影响育龄期女性的生活质量，其发病机制至今尚未阐明。调节性T细胞在机体免疫抑制中发挥关键作用，近年来大量研究证明，FOXP3相关免疫抑制可影响肿瘤微环境，在其发生发展中起到关键性作用，肿瘤微环境与内异症局部微环境相似，免疫功能异常在内异症发生发展中至关重要。TGF-β1可在免疫排斥和免疫抑制中发挥作用，参与子宫内膜异位症的发生发展过程。本文主要探究FOXP3、TGF-β1与内异症发病机制的相关性，为其免疫治疗提供新方向。\nAbstract:\nEndometriosis seriously affects the quality of life of women of childbearing age, and its pathogenesis has not been elucidated. Regulatory T cells play a key role in immunosuppression. In recent years, a large number of studies have proved that FOXP3-related immunosuppression can affect the tumor microenvironment and play a key role in its occurrence and development. Tumor microenviron-ment is similar to the local microenvironment of endometriosis, and immune dysfunction plays an important role in the occurrence and development of endometriosis. TGF-β1 may play a role in im-mune rejection and immunosuppression, and participate in the occurrence and development of endometriosis. This article mainly explores the correlation between FOXP3, TGF-β1 and the patho-genesis of endometriosis, and provides a new direction for its immunotherapy.\n文章引用：刘佳伟, 索静. FOXP3、TGF-β1在子宫内膜异位症诊疗中的研究进展[J]. 临床医学进展, 2024, 14(2): 2784-2788. https://doi.org/10.12677/ACM.2024.142393\n| [1] | Greene, R., Stratton, P., Cleary, S.D., et al. (2009) Diagnostic Experience among 4,334 Women Reporting Surgically Diagnosed Endometriosis. Fertility and Sterility, 91, 32-39. [Google Scholar] [CrossRef] [PubMed] |\n| [2] | Nnoaham, K.E., Hummelshoj, L., Webster, P., et al. (2019) Reprint of: Impact of Endometriosis on Quality of Life and Work Productivity: A Multicenter Study across Ten Countries. Fertility and Sterility, 112, e137-e152. [Google Scholar] [CrossRef] [PubMed] |\n| [3] | Shafrir Amy, L., Palmor Marissa, C., Fourquet, J., et al. (2021) Co-Occurrence of Immune-Mediated Conditions and Endometriosis among Adolescents and Adult Women. American Journal of Reproductive Immunology, 86, e13404. [Google Scholar] [CrossRef] [PubMed] |\n| [4] | Khan Khaleque, N., Yamamoto, K., Fujishita, A., et al. (2019) Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women with Early and Advanced Endometriosis. The Journal of Clinical Endocrinology & Metabolism, 104, 4715-4729. [Google Scholar] [CrossRef] [PubMed] |\n| [5] | Huang, N., Chi, H.B. and Qiao, J. (2020) Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases. Frontiers in Immunology, 11, Article 1023. [Google Scholar] [CrossRef] [PubMed] |\n| [6] | Li, Y.Y., Lin, Y.K., Li, Y., et al. (2022) SCM-198 Alleviates En-dometriosis by Suppressing Estrogen-ERα Mediated Differentiation and Function of CD4CD25 Regulatory T Cells. In-ternational Journal of Biological Sciences, 18, 1961-1973. [Google Scholar] [CrossRef] [PubMed] |\n| [7] | Hey-Cunningham, A.J., Riaz, A., Fromm, P.D., et al. (2022) Circulating and Endometrial Regulatory T Cell and Related Populations in Endometriosis and Infertility: Endometriosis Is Associated with Blunting of Endometrial Cyclical Effects and Reduced Proportions in Moderate-Severe Disease. Reproductive Sci-ences, 29, 229-242. [Google Scholar] [CrossRef] [PubMed] |\n| [8] | Robertson, S.A., Guerin, L.R., Moldenhauer, L.M., et al. (2009) Activating T Regulatory Cells for Tolerance in Early Pregnancy—The Contribution of Seminal Fluid. Journal of Repro-ductive Immunology, 83, 109-116. [Google Scholar] [CrossRef] [PubMed] |\n| [9] | Wang, J., Gong, R., Zhao, C., et al. (2023) Human FOXP3 and Tu-mour Microenvironment. Immunology, 168, 248-255. [Google Scholar] [CrossRef] [PubMed] |\n| [10] | Li, Y.N., Li, D., Yang, W., et al. (2016) Overexpression of the Transcrip-tion Factor FOXP3 in Lung Adenocarcinoma Sustains Malignant Character by Promoting G1/S Transition Gene CCND1. Tumor Biology, 37, 7395-7404. [Google Scholar] [CrossRef] [PubMed] |\n| [11] | Yonekura, S., Itoh, M., Shiratori, E., et al. (2018) FOXP3 Knockdown Inhibits the Proliferation and Reduces NOTCH1 Expression of T Cell Acute Lymphoblastic Leukemia Cells. BMC Research Notes, 11, Article No. 582. [Google Scholar] [CrossRef] [PubMed] |\n| [12] | Berbic, M., Hey-Cunningham, A.J., Ng, C., et al. (2010) The Role of Foxp3+ Regulatory T-Cells in Endometriosis: A Potential Controlling Mechanism for a Complex, Chronic Im-munological Condition. Human Reproduction, 25, 900-907. [Google Scholar] [CrossRef] [PubMed] |\n| [13] | 章舒, 李骏驰, 周争立, 等. 不同类型子宫内膜异位症及其周围组织中Foxp3和CD4+ CD25+ Treg的表达及意义[J]. 中国妇幼保健, 2017, 32(20): 4906-4909. |\n| [14] | Olkowska-Truchanowicz, J., Sztokfisz-Ignasiak, A., Zwierzchowska, A., et al. (2021) Endometriotic Peritoneal Fluid Stimulates Recruitment of CD4+CD25highFOXP3+ Treg Cells. Journal of Clinical Medicine, 10, Article 3789. [Google Scholar] [CrossRef] [PubMed] |\n| [15] | Ko, K., Yamazaki, S., Nakamura, K., et al. (2005) Treatment of Ad-vanced Tumors with Agonistic Anti-GITR mAb and Its Effects on Tumor-Infiltrating Foxp3+CD25+CD4+ Regulatory T Cells. Journal of Experimental Medicine, 202, 885-891. [Google Scholar] [CrossRef] [PubMed] |\n| [16] | Shi, X.K., Young, C.D., Zhou, Ho, M., et al. (2020) Transforming Growth Factor-β Signaling in Fibrotic Diseases and Can-cer-Associated Fibroblasts. Biomolecules, 10, Article 1666. [Google Scholar] [CrossRef] [PubMed] |\n| [17] | 胡琴, 张晨曦, 柯少瑞. 细胞自噬调控上皮间质转化在肺纤维化中的作用机制[J]. 实用医学杂志, 2022, 38(1): 38-44. |\n| [18] | Khan, K.N., Yamamoto, K., Fujishita, A., et al. (2019) Association between FOXP3 Regulatory T-Cells and Occurrence of Peritoneal Lesions in Women with Ovarian Endometrioma and Dermoid Cysts. Reproductive BioMedicine Online, 38, 857-869. [Google Scholar] [CrossRef] [PubMed] |\n| [19] | Muraoka, A., Suzuki, M., Hamaguchi, T., et al. (2023) Fusobacterium Infection Facilitates the Development of Endometriosis through the Phenotypic Transition of Endometrial Fibroblasts. Science Translational Medicine, 15, eadd1531. [Google Scholar] [CrossRef] [PubMed] |\n| [20] | 李冰冰, 谢苗, 郭亚楠, 等. TGF-β1、Smads在子宫内膜异位症中的表达和意义[J]. 中国生育健康杂志, 2022, 33(1): 33-37. |\n| [21] | Wang, X.Q., Zhou, W.J., Luo, X.Z., et al. (2017) Synergistic Effect of Regulatory T Cells and Proinflammatory Cytokines in Angiogenesis in the Endometriotic Milieu. Human Reproduction, 32, 1304-1317. [Google Scholar] [CrossRef] [PubMed] |\n| [22] | Hull, M.L., Johan, M.Z., Hodge, W.L., et al. (2012) Host-Derived TGFB1 Deficiency Suppresses Lesion Development in a Mouse Model of Endometriosis. American Journal of Patholo-gy: Official Publication of the American Association of Pathologists, 180, 880-887. [Google Scholar] [CrossRef] [PubMed] |\n| [23] | Liu, Z.H., Yi, L.S., Du, M.M., et al. (2019) Overexpression of TGF-β Enhances the Migration and Invasive Ability of Ectopic Endometrial Cells via ERK/MAPK Signaling Pathway. Experimental and Therapeutic Medicine, 17, 4457-4464. [Google Scholar] [CrossRef] [PubMed] |\n| [24] | Johnson, M.C., Torres, M., Alves, A., et al. (2005) Augmented Cell Survival in Eutopic Endometrium from Women with Endometriosis: Expression of c-myc, TGF-β1 and Bax Genes. Re-productive Biology and Endocrinology, 3, Article No. 45. [Google Scholar] [CrossRef] [PubMed] |\n| [25] | Wen, Y., Pang, L.L., Fan, L.X., et al. (2023) β-Sitosterol Inhibits the Proliferation of Endometrial Cells via Regulating Smad7-Mediated TGF-β/Smads Signaling Pathway. Cell Journal, 25, 554-563. |\n| [26] | Huang, S.H., Xiao, F.Y., Guo, S.W., et al. (2022) Tetramethylpyrazine Retards the Progression and Fibrogenesis of Endometriosis. Reproductive Sci-ences, 29, 1170-1187. [Google Scholar] [CrossRef] [PubMed] |\n| [27] | Wang, M., Zheng, L.W., Lin, R.X., et al. (2023) A Comprehensive Overview of Exosome lncRNAs: Emerging Biomarkers and Potential Therapeutics in Endo-metriosis. Frontiers in Endocrinology, 14, Article ID: 1199569. [Google Scholar] [CrossRef] [PubMed] |","source_license":"CC0","license_restricted":false}