Goserelin acetate (Zoladex) plus endometrial ablation for dysfunctional uterine bleeding: a 3-year follow-up evaluation

J. Donnez, Jacques Donnez, George A. Vilos, G Vilos, M J Gannon, M. Gannon, Rodolphe Maheux, R Maheux, M H Emanuel, Olav Istre, O Istre, AZTEC Study Group
Fertility and sterility · 2001 · vol. 75(3) , pp. 620–622 · doi:10.1016/s0015-0282(00)01767-2 · PMID:11239552 · W1985331401
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This study evaluated the efficacy and safety of goserelin acetate combined with endometrial ablation for dysfunctional uterine bleeding over a three-year period.

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Abstract

OBJECTIVE: To report the results of a 3-year follow-up evaluation of a trial comparing goserelin acetate depot injections with sham injections before endometrial ablation for the treatment of dysfunctional uterine bleeding (DUB). DESIGN: Prospective, randomized, double-blind, parallel-group study. SETTING: Thirty-seven centers in 12 countries. PATIENT(S): Three-hundred and fifty-eight premenopausal women aged over 30 years with DUB. INTERVENTION(S): Goserelin acetate (3.6 mg depot) every 28 days for 8 weeks, or sham depot every 28 days for 8 weeks, with endometrial ablation 6 weeks +/- 3 days after the first depot injection (i.e., when the endometrium is at its thinnest). The follow-up continued for 3 years. MAIN OUTCOME MEASURE(S): At the 3-year follow-up, bleeding in the previous 3 months and need for surgical intervention were recorded. RESULT(S): At 3 years, amenorrhea rates were 21% in the goserelin acetate group and 14% in the control group (estimated odds ratio, 1.8; 95% CI, 0.98-3.25; P=.0571). The surgical intervention rate (since the original procedure) was low and did not differ significantly between groups. For hysterectomy, it was 21% for the goserelin acetate group and 15% for the control group. For repeat ablations, it was 5.6% for the goserelin acetate group and 2.1% for the control group. CONCLUSION(S): Prethinning with goserelin acetate before endometrial ablation resulted in higher long-term amenorrhea rates than ablation without prethinning.

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MeSH descriptors

Endometrium Goserelin Uterine Hemorrhage Adult Amenorrhea Combined Modality Therapy Double-Blind Method Endometrium Female Goserelin Humans Hysterectomy Odds Ratio Prospective Studies Uterine Hemorrhage Uterine Hemorrhage Uterine Hemorrhage

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