Intrauterine instillation of trichloroacetic acid is effective for the treatment of dysfunctional uterine bleeding

Mustafa Küçük, Tulay Kilic Okman
In: Fertility and Sterility · 2005 · vol. 83(1) , pp. 189–194 · doi:10.1016/j.fertnstert.2004.05.100 · PMID:15652906 · W2003891844
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Trichloroacetic acid instilled into the uterus effectively treated dysfunctional uterine bleeding in this study.

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Abstract

ObjectiveTo evaluate the effectiveness of trichloroacetic acid (TCA) instillation into uterine cavity for the treatment of dysfunctional uterine bleeding (DUB).DesignProspective clinical study.SettingA university research hospital.Patient(s)Ninety women participated who had dysfunctional uterine bleeding.Intervention(s)Ninety-five percent of TCA was instilled into uterine cavity for endometrial ablation in women with dysfunctional uterine bleeding who want conservative treatment. Participants in group 1 received only TCA; participants in group 2 received a single dose of gonadotropin-releasing hormone analogue 1 month before the procedure.Main outcome measure(s)All participants underwent an evaluation that included cycle history, body mass index measurement, and transvaginal ultrasonography of pelvis, diagnostic hysteroscopy and endometrial biopsy.Result(s)At the end of 12 months of the treatment, amenorrhea rates in group 1 and group 2 were 26.7% vs. 31.1%, with pooled amenorrhea, hypomenorrhea, and eumenorrhea rates of 95.6% vs. 97.8%, respectively. There was no significant difference between the groups vis-a-vis postprocedure results. More than 90% of women who have this procedure are satisfied with the results. There were no observed negative effects or related complications with this treatment.Conclusion(s)An instillation of TCA into uterine cavity produces acceptable results and provides conservative management of DUB.

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