Gonadotropin-releasing hormone agonist inhibits estrone sulfatase expression of cystic endometriosis in the ovary

Kazuhiro Maitoko, Maitoko K, Hiroshi Sasaki, Sasaki H
Fertility and sterility · 2004 · vol. 82(2) , pp. 322–326 · doi:10.1016/j.fertnstert.2003.12.044 · PMID:15302278 · W2102959506
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This study found that gonadotropin-releasing hormone agonist treatment inhibits estrone sulfatase expression in the glandular epithelial cells of ovarian cystic endometriosis.

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Abstract

OBJECTIVE: To clarify the inhibitory effect of GnRH agonist on estrone (E(1)) sulfatase expression. DESIGN: Retrospective immunohistochemical study. SETTING: The Jikei University Hospital, Tokyo, Japan. PATIENT(S): Thirty-three women who had undergone cystectomy of the ovary or oophorectomy and were proved histopathologically to have cystic endometriosis in the ovary. INTERVENTION(S): Fifteen of the 33 patients were treated with GnRH agonists monthly for 2-6 months before surgery. The other 18 patients did not receive any hormonal therapy. Tissue sections were immunostained with an anti-E(1) sulfatase monoclonal antibody (KM1049) originating from human placenta. MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess the presence and localization of E(1) sulfatase and to describe any variations in its expression with or without treatment with GnRH agonist. RESULT(S): Immunostaining showed that E(1) sulfatase was localized only on the glandular epithelial cells of cystic endometriosis in the ovary. The immunostaining with anti-E(1) sulfatase proved that GnRH agonist inhibited E(1) sulfatase expression in the cystic endometriosis in the ovary. CONCLUSION(S): Gonadotropin-releasing hormone agonist inhibits E(1) sulfatase expression in cystic endometriosis in the ovary.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Enzyme Inhibitors Gonadotropin-Releasing Hormone Leuprolide Ovarian Cysts Sulfatases Adult Adult Delayed-Action Preparations Delayed-Action Preparations Endometriosis Endometriosis Endometriosis Endometriosis Enzyme Inhibitors Enzyme Inhibitors Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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