GONADOTROPIN-RELEASING HORMONE AGONISTS IN ENDOMETRIOSIS TREATMENT AND IN VITRO FERTILIZATION

Sofia Lider-Burciulescu, Romina‐Marina Sima, Liana Pleș
In: Journal of Surgical Sciences · 2018 · vol. 1(3) , pp. 51–56 · doi:10.33695/jss.v1i3.190 · W3134925732
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Gonadotropin-releasing hormone agonists are effective for endometriosis pain and infertility treatment, and increase pregnancy rates in IVF cycles, despite comparable efficacy to laparoscopic ablation in some cases.

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Abstract

Endometriosis is a chronic disease of unknown etiology defined as the presence of ectopic endometrial and it affects approximately 10% of women in reproductive age. Sequelae of endometriosis are represented by infertility and chronic pelvic pain. GnRHa (gonadotropin releasing hormone) represent one of one medical approaches that were tried for endometriosis treatment.Choosing between agonists and antagonists means to compare risks and benefits. The antagonists of GnRH are less used because of their many side effects. GnRH agonists have many advantages such as: lower cost, less side effects and shorter treatment. The GnRH therapy is not only useful in the treatment of endometriosis but also in IVF. Nowadays, researches shows that the laparoscopic ablation is as efficient as the GnRH agonists therapy, but also a postoperative therapy with GnRH is indicated. Several protocols are actually available for IVF and Embrio Transfer. Also recent researches proved that a postoperative therapy with GnRH agonists in patients with endometriosis associated infertility raised the pregnancy rate and reduced pelvic pain.GnRH agonists can be considered as a first line therapy when severe pain is involved or second-line treatment in endometriosis in case of failure of therapy with oral contraceptives or progestins. GnRH is more efficient in the protocol of FIV than in the treatment of endometriosis.

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Condition tags

endometriosischronic_pelvic_paininfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

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